2379336-76-0
Chemical Structure
Zosurabalpin
Synonym(s): Abx MCP; RG6006
- CAS No.: 2379336-76-0
- Formula:C43H50N8O5S
- Molecular Weight:790.97
IUPAC Name: 1,8-bis(methyl-d3)naphthalene-2,3,4,5,6,7-d6
InChIKey: NJFUXFYUHIHHOJ-FSEITFBQSA-N
SMILES: O=C1NCC2=C(C3=CC=C(C=C3)C(O)=O)C=CC=C2SC4=NC=CC=C4CN[C@H](C(N[C@H](C(N([C@H]1CC5=CNC6=CC=CC=C56)C)=O)CCCCN)=O)CCCN
Biological Activity: Zosurabalpin is a polypeptide antibiotic targeting LPS transporter (LptB2FGC complex), which can block the transport of LPS and lead to endotoxin accumulation in cells, and has shown excellent antibacterial activity against Carbapenem-resistant Acinetobacter baumanni (CRAB) [1] [2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Zosurabalpin | 99.28% | Zosurabalpin is a polypeptide antibiotic targeting LPS transporter (LptB2FGC complex), which can block the transport of LPS and lead to endotoxin accumulation in cells, and has shown excellent antibacterial activity against Carbapenem-resistant Acinetobacter baumanni (CRAB) . | ||||||||||||||||||||
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- [1]. Weng Q, et al. Zosurabalpin: a novel tethered macrocyclic peptide antibiotic that kills carbapenem-resistant Acinetobacter baumannii. MedComm (2020). 2024 Aug 11;5(8):e696. [Content Brief]
- [2]. Skudlarek JW, et al. Cerastecin Inhibition of the Lipooligosaccharide Transporter MsbA to Combat Acinetobacter baumannii: From Screening Impurity to In Vivo Efficacy. J Med Chem. 2024 Sep 12;67(17):15620-15675. [Content Brief]
Keywords
