2379336-76-0
Chemical Structure
Zosurabalpin
Synonym(s): Abx MCP; RG6006
- CAS No.: 2379336-76-0
- Formula:C43H50N8O5S
- Molecular Weight:790.97
IUPAC Name: 1,8-bis(methyl-d3)naphthalene-2,3,4,5,6,7-d6
InChIKey: NJFUXFYUHIHHOJ-FSEITFBQSA-N
SMILES: O=C1NCC2=C(C3=CC=C(C=C3)C(O)=O)C=CC=C2SC4=NC=CC=C4CN[C@H](C(N[C@H](C(N([C@H]1CC5=CNC6=CC=CC=C56)C)=O)CCCCN)=O)CCCN
Biological Activity: Zosurabalpin (Abx MCP; RG6006) is a lipopolysaccharide (LPS) transport inhibitor that targets the LptB2FGC complex. Zosurabalpin blocks the transport of LPS from the inner membrane to the outer membrane, leading to intracellular toxic accumulation of LPS and bacterial death. Zosurabalpin exhibits potent antibacterial activity against carbapenem-resistant Acinetobacter baumannii (CRAB) and shows in vivo efficacy in mouse infection models. Zosurabalpin can be used for research on CRAB infections, including pneumonia and sepsis[1][2][3][4].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Zosurabalpin | 98.85% | Zosurabalpin (Abx MCP; RG6006) is a lipopolysaccharide (LPS) transport inhibitor that targets the LptB2FGC complex. Zosurabalpin blocks the transport of LPS from the inner membrane to the outer membrane, leading to intracellular toxic accumulation of LPS and bacterial death. Zosurabalpin exhibits potent antibacterial activity against carbapenem-resistant Acinetobacter baumannii (CRAB) and shows in vivo efficacy in mouse infection models. Zosurabalpin can be used for research on CRAB infections, including pneumonia and sepsis. | ||||||||||||||||||||
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- [1]. Terzi I, et al. Zosurabalpin: an antibiotic with a new mechanism of action against carbapenem-resistant Acinetobacter baumannii. Infez Med. 2025 Jun 1;33(2):175-181.
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[2]. Zhenlin Lai, et al. A narrative review for antibacterials design and modification targeting outer membrane against Gram-negative bacteria, Animals and Zoonoses,
Volume 2, Issue 2, 2026, Pages 163-172, ISSN 2950-2489, - [3]. Zampaloni C, et al. A novel antibiotic class targeting the lipopolysaccharide transporter. Nature. 2024 Jan;625(7995):566-571. [Content Brief]
- [4]. Pahil KS, et al. A new antibiotic traps lipopolysaccharide in its intermembrane transporter. Nature. 2024 Jan;625(7995):572-577. [Content Brief]
Keywords
