2417408-46-7
Chemical Structure
YX-2-107
- CAS No.: 2417408-46-7
- Formula:C45H51N11O9
- Molecular Weight:889.95
IUPAC Name: ((S)-2-((S)-2-((S)-2-((S)-2-((S)-2-((S)-2-((S)-2-((S)-2-(2-aminobenzamido)propanamido)-3-phenylpropanamido)propanamido)-3-phenylpropanamido)-4-carboxybutanamido)-3-methylbutanamido)-3-phenylpropanamido)-3-(4-hydroxy-3-nitrophenyl)propanoyl)-L-aspartic acid
InChIKey: JNYCZFGLJGFFEL-UHFFFAOYSA-N
SMILES: O=C1NC(C(CC1)N2C(C3=C(C2=O)C(OCC(NCCCCNCC(N4CCN(CC4)C5=CN=C(NC6=NC(N(C7CCCC7)C(C(C(C)=O)=C8C)=O)=C8C=N6)C=C5)=O)=O)=CC=C3)=O)=O
Biological Activity: YX-2-107 is a PROTAC (IC50= 4.4 nM) that selectively degrades CDK6. YX-2-107 effectively inhibits RB phosphorylation and FOXM1 expression in vitro and inhibits the development of Ph+ ALL in rats. YX-2-107 can be used in the study of Ph chromosome-positive (Ph+) acute lymphoblastic leukemia (ALL)[1].
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YX-2-107 | 98.60% | YX-2-107 is a PROTAC (IC50= 4.4 nM) that selectively degrades CDK6. YX-2-107 effectively inhibits RB phosphorylation and FOXM1 expression in vitro and inhibits the development of Ph+ ALL in rats. YX-2-107 can be used in the study of Ph chromosome-positive (Ph+) acute lymphoblastic leukemia (ALL). | ||||||||||||||||||||
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Keywords
