2428389-67-5
Chemical Structure
hCAI/II-IN-5
- CAS No.: 2428389-67-5
- Formula:C21H18Cl2N8O4S2
- Molecular Weight:581.45
IUPAC Name: 4,4'-((6-((3,4-dichlorophenyl)amino)-1,3,5-triazine-2,4-diyl)bis(azanediyl))dibenzenesulfonamide
InChIKey: VIGGRACLECKMDI-UHFFFAOYSA-N
SMILES: ClC1=CC=C(NC2=NC(NC3=CC=C(S(=O)(N)=O)C=C3)=NC(NC4=CC=C(S(=O)(N)=O)C=C4)=N2)C=C1Cl
Biological Activity: hCAI/II-IN-5 (compound MZ8) is a potent hCA I and hCA II (human carbonic anhydrase isoenzymes I and II) inhibitor, with IC50 values of 37.88 and 45.23 nM, respectively. hCAI/II-IN-5 also shows inhibition profile against α-Glycosidase and AChE, with IC50 values of 48.98 and 420.14 nM, respectively. hCAI/II-IN-5 can be used for the research of many diseases such as diabetes, Alzheimer’s disease, heart failure, ulcer, and epilepsy[1].
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hCAI/II-IN-5 | hCAI/II-IN-5 (compound MZ8) is a potent hCA I and hCA II (human carbonic anhydrase isoenzymes I and II) inhibitor, with IC50 values of 37.88 and 45.23 nM, respectively. hCAI/II-IN-5 also shows inhibition profile against α-Glycosidase and AChE, with IC50 values of 48.98 and 420.14 nM, respectively. hCAI/II-IN-5 can be used for the research of many diseases such as diabetes, Alzheimer’s disease, heart failure, ulcer, and epilepsy. | |||||||||||||||||||||
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Keywords
