254889-31-1
254889-31-1
Chemical Structure
2-Hydroxy nevirapine
Synonym(s): 2-OH NVP
- CAS No.: 254889-31-1
- Formula:C15H14N4O2
- Molecular Weight:282.30
IUPAC Name: 11-cyclopropyl-4-methyl-5,11-dihydro-1H-dipyrido[3,2-b:2',3'-e][1,4]diazepine-2,6-dione
InChIKey: LFZSOJABLBVGRJ-UHFFFAOYSA-N
SMILES: O=C1C=C(C)C(N2)=C(N1)N(C3CC3)C4=NC=CC=C4C2=O
Biological Activity: 2-Hydroxy nevirapine (2-OH NVP) is a phase I metabolite of Nevirapine (HY-10570) and an Aryl Hydrocarbon Receptor activator. It induces hepatic Apolipoprotein A1 levels and modulates paraoxonase-1 enzyme activity. 2-Hydroxy nevirapine is used in research on atherosclerosis and HIV-1 infection[1][2][3][4].
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2-Hydroxy nevirapine | 2-Hydroxy nevirapine (2-OH NVP) is a phase I metabolite of Nevirapine (HY-10570) and an Aryl Hydrocarbon Receptor activator. It induces hepatic Apolipoprotein A1 levels and modulates paraoxonase-1 enzyme activity. 2-Hydroxy nevirapine is used in research on atherosclerosis and HIV-1 infection. | |||||||||||||||||||||
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2-Hydroxy nevirapine-d3 | 2-Hydroxy nevirapine-d3 (2-OH NVP-d3) is the deuterated-labeled 2-Hydroxy nevirapine (2-OH NVP) (HY-W739986). 2-Hydroxy nevirapine (2-OH NVP) is a phase I metabolite of Nevirapine (HY-10570) and an Aryl Hydrocarbon Receptor activator. It induces hepatic Apolipoprotein A1 levels and modulates paraoxonase-1 enzyme activity. 2-Hydroxy nevirapine is used in research on atherosclerosis and HIV-1 infection. | |||||||||||||||||||||
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References
- [1]. Marinho AT, et al. The 2-hydroxy-nevirapine metabolite as a candidate for boosting apolipoprotein A1 and for modulating anti-HDL antibodies. Pharmacological research. 2021 Mar;165:105446. [Content Brief]
- [2]. Aline T, et al. Development and validation of an HPLC-UV method for quantifying nevirapine and its main phase I metabolites in human blood. Anal. Methods 2014; 6 (5): 1575-1580.
- [3]. Pinheiro PF, et al. Sex differences in hepatic and intestinal contributions to nevirapine biotransformation in rats. Chemico-biological interactions. 2015 May 25;233:115-21.
- [4]. Marinho AT, et al. Nevirapine modulation of paraoxonase-1 in the liver: An in vitro three-model approach. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences. 2016 Jan 20;82:147-53.
