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Cat. No.: HY-W739986

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2-Hydroxy nevirapine

Name: 2-Hydroxy nevirapine
Brand: MedChemExpress
SKU: HY-W739986
Availability: PreOrder

(Synonyms: 2-OH NVP)

2-Hydroxy nevirapine (2-OH NVP) is a phase I metabolite of Nevirapine (HY-10570) and an Aryl Hydrocarbon Receptor activator. It induces hepatic Apolipoprotein A1 levels and modulates paraoxonase-1 enzyme activity. 2-Hydroxy nevirapine is used in research on atherosclerosis and HIV-1 infection.

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CAS No.: 254889-31-1
화학식: C₁₅H₁₄N₄O₂
분자량:282.30

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

2-Hydroxy nevirapine Chemical Structure

CAS No.: 254889-31-1

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Biological Activity
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Biological Activity

제품 설명

In Vitro

2-OH-NVP (300 μM; 12 days) increases ApoA1 levels by 86% after 12 days of incubation in 3D primary rat hepatocyte spheroid cultures^[1].
2-Hydroxy-nevirapine (300 μM; 4 days) induces CYP1A1/1A2 activity in 3D primary cultures of rat hepatocytes^[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

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Chemical Information

CAS No. 254889-31-1
분자량 282.30
화학식 C₁₅H₁₄N₄O₂
SMILES

O=C1C=C(C)C(N2)=C(N1)N(C3CC3)C4=NC=CC=C4C2=O
Synonyms

2-OH NVP
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Handling Instructions (2659 KB)

References

[1]. Marinho AT, et al. The 2-hydroxy-nevirapine metabolite as a candidate for boosting apolipoprotein A1 and for modulating anti-HDL antibodies. Pharmacological research. 2021 Mar;165:105446. [Content Brief]

[2]. Aline T, et al. Development and validation of an HPLC-UV method for quantifying nevirapine and its main phase I metabolites in human blood. Anal. Methods 2014; 6 (5): 1575-1580.

[3]. Pinheiro PF, et al. Sex differences in hepatic and intestinal contributions to nevirapine biotransformation in rats. Chemico-biological interactions. 2015 May 25;233:115-21.

[4]. Marinho AT, et al. Nevirapine modulation of paraoxonase-1 in the liver: An in vitro three-model approach. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences. 2016 Jan 20;82:147-53.

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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