2667681-57-2
2667681-57-2
Chemical Structure
IRAK4-IN-13
- CAS No.: 2667681-57-2
- Formula:C24H27N9O
- Molecular Weight:457.53
IUPAC Name: 4-(1-methylcyclopropoxy)-N-(1-(1-methylpiperidin-4-yl)-1H-pyrazol-4-yl)-6-(pyrimidin-5-yl)pyrido[3,2-d]pyrimidin-2-amine
InChIKey: QQIQOMIKWUAMAA-UHFFFAOYSA-N
SMILES: CN1CCC(N2N=CC(NC3=NC(OC4(C)CC4)=C5C(C=CC(C6=CN=CN=C6)=N5)=N3)=C2)CC1
Biological Activity: IRAK4-IN-13 (compound 21) is a potent and selective IRAK4 inhibitor with an IC50 of 0.6 nM. IRAK4-IN-13 shows high metabolic clearance with human liver microsomes (HLM) intrinsic clearance is 96 µL/min/mg[1].
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IRAK4-IN-13 | IRAK4-IN-13 (compound 21) is a potent and selective IRAK4 inhibitor with an IC50 of 0.6 nM. IRAK4-IN-13 shows high metabolic clearance with human liver microsomes (HLM) intrinsic clearance is 96 µL/min/mg. | |||||||||||||||||||||
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