IRAK4-IN-13
IRAK4-IN-13 (compound 21) is a potent and selective IRAK4 inhibitor with an IC50 of 0.6 nM. IRAK4-IN-13 shows high metabolic clearance with human liver microsomes (HLM) intrinsic clearance is 96 µL/min/mg.
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- CAS. Nr.: 2667681-57-2
- Formel: C24H27N9O
- Molecular Weight:457.53
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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IRAK4 0.6 nM (IC50) |
IRAK4-IN-13 (compound 21) shows cell pIRAK4 potencies with an IC50 of 0.024 µM[1].
IRAK4-IN-13 (compound 21) shows selectivity with IC50s of 0.0006, 0.002, 0.044, 1.2, 0.018, 0.019, 0.082, 0.036 µM for IRAK4, IRAK1, BTK, Flt3, PI3Kδ, TRKa, TRKb, TRKc, respectively[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS. Nr. 2667681-57-2
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Molecular Weight 457.53
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Formel C24H27N9O
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SMILES
CN1CCC(N2N=CC(NC3=NC(OC4(C)CC4)=C5C(C=CC(C6=CN=CN=C6)=N5)=N3)=C2)CC1
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
IRAK4-IN-13 Related Classifications
HY-146111 Related Classifications
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