2. Immunology/Inflammation
  3. IRAK
  4. IRAK4-IN-13

IRAK4-IN-13 (compound 21) is a potent and selective IRAK4 inhibitor with an IC50 of 0.6 nM. IRAK4-IN-13 shows high metabolic clearance with human liver microsomes (HLM) intrinsic clearance is 96 µL/min/mg.

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IRAK4-IN-13 Chemical Structure

IRAK4-IN-13 Chemical Structure

CAS No. : 2667681-57-2

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IRAK4-IN-13 Related Antibodies

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Description

IRAK4-IN-13 (compound 21) is a potent and selective IRAK4 inhibitor with an IC50 of 0.6 nM. IRAK4-IN-13 shows high metabolic clearance with human liver microsomes (HLM) intrinsic clearance is 96 µL/min/mg[1].

IC50 & Target[1]

IRAK4

0.6 nM (IC50)

In Vitro

IRAK4-IN-13 (compound 21) shows cell pIRAK4 potencies with an IC50 of 0.024 µM[1].
IRAK4-IN-13 (compound 21) shows selectivity with IC50s of 0.0006, 0.002, 0.044, 1.2, 0.018, 0.019, 0.082, 0.036 µM for IRAK4, IRAK1, BTK, Flt3, PI3Kδ, TRKa, TRKb, TRKc, respectively[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

IRAK4-IN-13 Related Antibodies
Molecular Weight

457.53

Formula

C24H27N9O
CAS No.
SMILES

CN1CCC(N2N=CC(NC3=NC(OC4(C)CC4)=C5C(C=CC(C6=CN=CN=C6)=N5)=N3)=C2)CC1
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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IRAK4-IN-13 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

IRAK4-IN-132667681-57-2IRAKInterleukin-1 receptor associated kinaseIL-1R associated kinasemetabolic clearanceCaco2 cellsHuman Hepatocytescell pIRAK4Inhibitorinhibitorinhibit

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IRAK4-IN-13
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HY-146111
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