2864442-74-8
Chemical Structure
URAT1-IN-16
- CAS No.: 2864442-74-8
- Formula:C28H23BrN4O3S2
- Molecular Weight:607.54
InChIKey: VHLVEUSCOXYRKE-UHFFFAOYSA-N
SMILES: BrC(C=C1)=CC=C1S(NC(C(C)SC2=NC3=NC=CC=C3N2C4=CC=C(C5CC5)C6=C4C=CC=C6)=O)(=O)=O
Biological Activity: URAT1-IN-16 is an orally active URAT1 inhibitor with an IC50 value of 0.19 μM. URAT1-IN-16 also functions as an NLRP3 inflammasome pathway inhibitor by effectively suppressing mature IL-1β secretion (IC50 = 2.52 μM). URAT1-IN-16 exhibits remarkable serum uric acid-lowering and anti-inflammatory activities in vivo, and can be used for hyperuricemia and gout research[1].
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URAT1-IN-16 | URAT1-IN-16 is an orally active URAT1 inhibitor with an IC50 value of 0.19 μM. URAT1-IN-16 also functions as an NLRP3 inflammasome pathway inhibitor by effectively suppressing mature IL-1β secretion (IC50 = 2.52 μM). URAT1-IN-16 exhibits remarkable serum uric acid-lowering and anti-inflammatory activities in vivo, and can be used for hyperuricemia and gout research. | |||||||||||||||||||||
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Keywords
