3084814-46-7
3084814-46-7
Chemical Structure
sEH-IN-21
- CAS No.: 3084814-46-7
- Formula:C30H40N4O5S
- Molecular Weight:568.73
SMILES: O=C1C(N[C@@H]2CC[C@@H](NC(N[C@]3(C4)C[C@H](C5)C[C@]4(C)C[C@@]5(C)C3)=O)CC2)=C(NS(C6=CC=C(C)C=C6)(=O)=O)C1=O
Biological Activity: sEH-IN-21 is an orally active sEH inhibitor with IC50s of 0.1 nM for hsEH and msEH. sEH-IN-21 potently inhibits NF-κB signaling pathways. sEH-IN-21 shows a strong anti-inflammatory activity, decreases the release of IL-6 and TNF-α and maintained the integrity of the intestinal barrier. sEH-IN-21 can be used for the study of inflammatory bowel disease (IBD)[1].
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sEH-IN-21 | sEH-IN-21 is an orally active sEH inhibitor with IC50s of 0.1 nM for hsEH and msEH. sEH-IN-21 potently inhibits NF-κB signaling pathways. sEH-IN-21 shows a strong anti-inflammatory activity, decreases the release of IL-6 and TNF-α and maintained the integrity of the intestinal barrier. sEH-IN-21 can be used for the study of inflammatory bowel disease (IBD). | |||||||||||||||||||||
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