312929-49-0
312929-49-0
Chemical Structure
A1/A3 AR antagonist 1
- CAS. Nr.: 312929-49-0
- Formula:C24H18N2O3S
- Molecular Weight:414.48
IUPAC Name: N-(5-benzoyl-4-phenylthiazol-2-yl)-4-methoxybenzamide
InChIKey: GWTAISADZNYBMN-UHFFFAOYSA-N
SMILES: COC1=CC=C(C=C1)C(NC2=NC(C3=CC=CC=C3)=C(S2)C(C4=CC=CC=C4)=O)=O
Biological Activity: A1/A3 AR antagonist 1 (compound 10) is a potent adenosine 1 (A1) and adenosine 3 (A3) receptor dual antagonist with Kis of 36.7 nM, 25.4 nM and 1.47 nM for human A1, human A3 and rat A1, respectively. A1/A3 AR antagonist 1 can be used for researching kidney failure, inflammatory pulmonary diseases, and Alzheimer’s disease[1].
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A1/A3 AR antagonist 1 | A1/A3 AR antagonist 1 (compound 10) is a potent adenosine 1 (A1) and adenosine 3 (A3) receptor dual antagonist with Kis of 36.7 nM, 25.4 nM and 1.47 nM for human A1, human A3 and rat A1, respectively. A1/A3 AR antagonist 1 can be used for researching kidney failure, inflammatory pulmonary diseases, and Alzheimer’s disease. | |||||||||||||||||||||
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