3262-64-4
3262-64-4
Chemical Structure
S-Propargylcysteine
Synonym(s): SPRC
- CAS No.: 3262-64-4
- Formula:C6H9NO2S
- Molecular Weight:159.21
IUPAC Name: S-(prop-2-yn-1-yl)-L-cysteine
InChIKey: JAKVEOCMEMGHGB-YFKPBYRVSA-N
SMILES: O=C([C@H](CSCC#C)N)O
Biological Activity: S-Propargylcysteine (SPRC), a structural analog of S-allyl cysteine (SAC), is a slow H2S-releasing compound. S-Propargylcysteine reduces Ca2+ accumulation and inflammatory cytokines, inhibits STAT3, and elevates p53 and Bax. S-Propargylcysteine has anti-inflammatory activity and protects mice against acute pancreatitis. S-Propargylcysteine also has cardioprotective, neuroprotective acitivties[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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S-Propargylcysteine | 97.0% | S-Propargylcysteine (SPRC), a structural analog of S-allyl cysteine (SAC), is a slow H2S-releasing compound. S-Propargylcysteine reduces Ca2+ accumulation and inflammatory cytokines, inhibits STAT3, and elevates p53 and Bax. S-Propargylcysteine has anti-inflammatory activity and protects mice against acute pancreatitis. S-Propargylcysteine also has cardioprotective, neuroprotective acitivties. | ||||||||||||||||||||
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L-Homopropargylglycine | 98.0% | L-Homopropargylglycine is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs. L-homopropargylglycine is an amino acid analog of methionine containing an alkyne moiety that can undergo a classic click chemical reaction with azide containing Alexa Fluor. | ||||||||||||||||||||
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L-Homopropargylglycine hydrochloride | 98.0% | L-Homopropargylglycine hydrochloride is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs. L-homopropargylglycine hydrochloride is an amino acid analog of methionine containing an alkyne moiety that can undergo a classic click chemical reaction with azide containing Alexa Fluor. | ||||||||||||||||||||
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H-L-Ser(Propargyl)-OH | H-L-Ser(Propargyl)-OH is a click chemistry reagent containing an alkyne group. | |||||||||||||||||||||
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H-L-Ser(Propargyl)-OH hydrochloride | H-L-Ser(Propargyl)-OH hydrochloride is a click chemistry reagent containing an alkyne group. | |||||||||||||||||||||
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L-Propargylglycine | 99.95% | (S)-2-Aminopent-4-ynoic acid is a synthetic amino acid. (S)-2-Aminopent-4-ynoic acid can be used in synthesis of folate-conjugates and corresponding metal-chelate complexes. (S)-2-Aminopent-4-ynoic acid is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. | ||||||||||||||||||||
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S-Allyl-L-cysteine (Standard) | 99.87% | S-Allyl-L-cysteine (Standard) is the analytical standard of S-Allyl-L-cysteine. This product is intended for research and analytical applications. S-Allyl-L-cysteine, one of the organosulfur compounds found in AGE, possess various biological effects including neurotrophic activity, anti-cancer activity, anti-inflammatory activity. | ||||||||||||||||||||
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DL-Propargylglycine | 99.68% | DL-Propargylglycine is a Glycine (HY-Y0966) derivative. DL-Propargylglycine is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. | ||||||||||||||||||||
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S-Allyl-D-cysteine | 97.0% | S-Allyl-D-cysteine is a cysteine derivative. | ||||||||||||||||||||
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DL-Propargylglycine hydrochloride | DL-Propargylglycine hydrochloride is an irreversible and selective CSE inhibitor that blocks the biosynthesis of endogenous hydrogen sulfide. DL-Propargylglycine hydrochloride induces ROS and TGF-β1 expression. DL-Propargylglycine hydrochloride downregulates carotid ACE2 and Ang-(1-7), and elevates Ang II. DL-Propargylglycine hydrochloride upregulates ICAM-1/LFA-1, exacerbating Aspirin (HY-14654)-induced gastric mucosal injury. DL-Propargylglycine hydrochloride is used in research on diabetes-induced liver injury, diabetic nephropathy, atherosclerosis, gastric mucosal injury, hemorrhagic shock, and Streptococcus agalactiae infection. | |||||||||||||||||||||
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Homopropargylglycine | 98.54% | Homopropargylglycine is a Methionine (HY-13694) analogue. Homopropargylglycine is incorporated at a suitable rate into newly synthesized proteins in a variety of systems, including mammalian cell culture. Homopropargylglycine can be used to identify old and new protein populations. Homopropargylglycine is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. | ||||||||||||||||||||
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References
- [1]. Sidhapuriwala JN, et al. Effects of S-propargyl-cysteine (SPRC) in caerulein-induced acute pancreatitis in mice. PLoS One. 2012;7(3):e32574. [Content Brief]
- [2]. Wen YD, et al. The Pharmacological Effects of S-Propargyl-Cysteine, a Novel Endogenous H2S-Producing Compound. Handb Exp Pharmacol. 2015;230:325-36. [Content Brief]
