361198-09-6
Chemical Structure
F0911-7667
- CAS No.: 361198-09-6
- Formula:C26H19ClN4O3S2
- Molecular Weight:535.04
IUPAC Name: (E)-4-(((benzo[d][1,3]dioxol-5-ylmethyl)amino)methylene)-2-(benzo[d]thiazol-2-yl)-5-(((4-chlorophenyl)thio)methyl)-2,4-dihydro-3H-pyrazol-3-one
InChIKey: BCCAZPLEJITKJU-CPNJWEJPSA-N
SMILES: O=C1N(C2=NC3=CC=CC=C3S2)N=C(CSC4=CC=C(Cl)C=C4)/C1=C\NCC5=CC=C(OCO6)C6=C5
Biological Activity: F0911-7667 is a SIRT1 activator that induces autophagic cell death in U87MG and T98G cells by activating the AMPK-mTOR-ULK complex. CWR tripeptide was also identified as a SIRT1 activator that reduced p53 acetylation in IMR32 neuroblastoma cells and protected cells from cell death induced by Aβ fragments[1].
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F0911-7667 | F0911-7667 is a SIRT1 activator that induces autophagic cell death in U87MG and T98G cells by activating the AMPK-mTOR-ULK complex. CWR tripeptide was also identified as a SIRT1 activator that reduced p53 acetylation in IMR32 neuroblastoma cells and protected cells from cell death induced by Aβ fragments. | |||||||||||||||||||||
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