380221-63-6
Chemical Structure
UK-432097
- CAS No.: 380221-63-6
- Formula:C40H47N11O6
- Molecular Weight:777.87
IUPAC Name: 6-((2,2-diphenylethyl)amino)-9-((2R,3R,4S,5S)-5-(ethylcarbamoyl)-3,4-dihydroxytetrahydrofuran-2-yl)-N-(2-(3-(1-(pyridin-2-yl)piperidin-4-yl)ureido)ethyl)-9H-purine-2-carboxamide
InChIKey: ZOTHAEBAWXWVID-HXEFRTELSA-N
SMILES: O[C@H]1[C@@H](O[C@H](C(NCC)=O)[C@H]1O)N2C3=NC(C(NCCNC(NC4CCN(C5=CC=CC=N5)CC4)=O)=O)=NC(NCC(C6=CC=CC=C6)C7=CC=CC=C7)=C3N=C2
Biological Activity: UK-432097 is a highly potent and selective A2AAR agonist with a pKi of 8.4 for human A2AAR. UK-432097 has anti-inflammatory and anti-aggregatory properties. UK-432097 has the potential for COPD (Chronic Obstructive Pulmonary Disease) research[1][2][3].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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UK-432097 | 98.9% | UK-432097 is a highly potent and selective A2AAR agonist with a pKi of 8.4 for human A2AAR. UK-432097 has anti-inflammatory and anti-aggregatory properties. UK-432097 has the potential for COPD (Chronic Obstructive Pulmonary Disease) research. | ||||||||||||||||||||
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References
- [1]. Fei Xu, et al. Structure of an agonist-bound human A2A adenosine receptor. Science. 2011 Apr 15;332(6027):322-7. [Content Brief]
- [2]. Kenneth A Jacobson, et al. Historical and Current Adenosine Receptor Agonists in Preclinical and Clinical Development. Front Cell Neurosci. 2019 Mar 28;13:124. [Content Brief]
- [3]. J Daniel Hothersall, et al. Structure-Activity Relationships of the Sustained Effects of Adenosine A2A Receptor Agonists Driven by Slow Dissociation Kinetics. Mol Pharmacol. 2017 Jan;91(1):25-38. [Content Brief]
