4199-09-1
4199-09-1
Chemical Structure
(S)-(-)-Propranolol
- CAS No.: 4199-09-1
- Formula:C16H21NO2
- Molecular Weight:259.34
InChIKey: AQHHHDLHHXJYJD-AWEZNQCLSA-N
SMILES: CC(C)NC[C@H](O)COC1=CC=CC2=C1C=CC=C2
Biological Activity: (S)-(-)-Propranolol is the active isomer of Propranolol (HY-B0573B), with 98-fold greater activity than (R)-(+)-Propranolol. (S)-(-)-Propranolol produces antinociception-related phenotypes in mouse models, accompanied by sedative and ataxic side effects. (S)-(-)-Propranolol can be used in research related to hypertension, myocardial infarction, and pain[1][2].
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(S)-(-)-Propranolol | (S)-(-)-Propranolol is the active isomer of Propranolol (HY-B0573B), with 98-fold greater activity than (R)-(+)-Propranolol. (S)-(-)-Propranolol produces antinociception-related phenotypes in mouse models, accompanied by sedative and ataxic side effects. (S)-(-)-Propranolol can be used in research related to hypertension, myocardial infarction, and pain. | |||||||||||||||||||||
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References
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[1]. Veloo R A. Synthesis of enantiomerically pure (S)-(-)-propranolol from sorbitol. Tetrahedron: Asymmetry, 1993, 4: 2401-2404.
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[2]. Martin L J, et al. Differences in the Antinociceptive Effects and Binding Properties of Propranolol and Bupranolol Enantiomers. The Journal of Pain, 2015, 16: 1321-1333.
