(S)-(-)-Propranolol
Based on 2 publication(s) in Google Scholar
(S)-(-)-Propranolol is the active isomer of Propranolol (HY-B0573B), with 98-fold greater activity than (R)-(+)-Propranolol. (S)-(-)-Propranolol produces antinociception-related phenotypes in mouse models, accompanied by sedative and ataxic side effects. (S)-(-)-Propranolol can be used in research related to hypertension, myocardial infarction, and pain.
For research use only. We do not sell to patients.
- CAS No.: 4199-09-1
- Formula: C16H21NO2
- Molecular Weight:259.34
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) (S)-(-)-Propranolol
MoreAll Adrenergic Receptor Isoforms
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Biological Activity
Description
IC50 & Target
[1]|
β-adrenoceptor |
In Vitro
(S)-(-)-propranolol can be synthesized from D-Sorbitol (HY-B0400)[1].
(S)-(-)-Propranolol is the active isomer of Propranolol (HY-B0573B), a non-selective and blood-brain barrier-permeable β-adrenergic receptor antagonist[1][2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
(S)-(-)-Propranolol (30-60 mg/kg; 60 min after administration) impairs motor coordination and induces ataxia in mice in the rotarod test, with an ataxia ED50 = 22.2 mg/kg[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:CD‑1 (ICR:Crl) mice (6‑12 weeks old; formalin‑induced inflammatory pain model).[2]
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Dosage:1, 3, 10, 30 mg/kg
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Administration:Intraperitoneal (IP) injection; single injection; measured at 60 min post‑administration
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Result:roduces dose‑dependent antinociceptive effect; AD50 = 35.0 mg/kg for early phase, AD50 = 25.5 mg/kg for late phase
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Animal Model:CD‑1 (ICR:Crl) mice (6‑12 weeks old; motor‑function evaluation via Rota‑Rod test)[2]
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Dosage:10, 30, 60 mg/kg
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Administration:Intraperitoneal (IP) injection; single injection; measured at 60 min post‑administration
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Result:Impairs motor coordination and induces ataxia, with ataxia ED50 = 22.2 mg/kg.
Chemical Information
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CAS No. 4199-09-1
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Molecular Weight 259.34
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Formula C16H21NO2
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SMILES
CC(C)NC[C@H](O)COC1=CC=CC2=C1C=CC=C2
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (2)
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Journal Impact Factor
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Most Recent
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Cancer Discov
Myofibroblasts Induce Neuroplasticity to Promote Pancreatic Inflammation and Cancer Progression. [Abstract]2026 Feb 9. PMID: 41661076 -
Arterioscler Thromb Vasc Biol
TGF-β1 Promotes Angiogenesis via Endothelial-to-Mesenchymal Transition in Infantile Hemangioma. [Abstract]2025 Aug 21. PMID: 40836919
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
(S)-(-)-Propranolol Related Classifications
HY-B0573D Related Classifications
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