473-90-5
473-90-5
Chemical Structure
Mesoxalate
Synonym(s): Ketomalonic acid; Mesoxalic acid; Oxomalonic acid
- CAS No.: 473-90-5
- Formula:C3H2O5
- Molecular Weight:118.04
IUPAC Name: 2-oxomalonic acid
InChIKey: XEEVLJKYYUVTRC-UHFFFAOYSA-N
SMILES: O=C(C(C(O)=O)=O)O
Biological Activity: Mesoxalate (Ketomalonic acid) a dicarboxylic acid and a ketonic acid which blocks HIV-1 reverse transcriptase (RT), with the IC50 of 2.2 μM[1][2].
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Mesoxalate | Mesoxalate (Ketomalonic acid) a dicarboxylic acid and a ketonic acid which blocks HIV-1 reverse transcriptase (RT), with the IC50 of 2.2 μM. | |||||||||||||||||||||
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References
- [1]. Jean A Bernatchez, et al. Derivatives of mesoxalic acid block translocation of HIV-1 reverse transcriptase. J Biol Chem. 2015 Jan 16;290(3):1474-84. [Content Brief]
- [2]. W R Davis, et al. Inhibition of HIV-1 reverse transcriptase-catalyzed DNA strand transfer reactions by 4-chlorophenylhydrazone of mesoxalic acid. Biochemistry. 2000 Nov 21;39(46):14279-91. [Content Brief]
Keywords
