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Cat. No.: HY-114634

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Mesoxalate

Name: Mesoxalate
Brand: MedChemExpress
SKU: HY-114634
Availability: PreOrder

(Synonyms: Ketomalonic acid; Mesoxalic acid; Oxomalonic acid)

Mesoxalate (Ketomalonic acid) is an orally active antidiabetic agent. Mesoxalate increases pancreatic insulin content. Mesoxalate reduces dietary hyperglycemia. Mesoxalate inhibits Epinephrine-induced hyperglycemia in rabbits and exacerbates Alloxan (HY-116823)-induced hypoglycemic convulsions. Mesoxalate exerts no antidiabetic effect in pancreatectomized dogs and fails to reduce the susceptibility of rabbits to Alloxan-induced diabetes. Mesoxalate can be used in diabetes-related research.

For research use only. We do not sell to patients.

CAS No.: 473-90-5
Formula: C₃H₂O₅
Molecular Weight:118.04

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (267 KB)

Mesoxalate Chemical Structure

CAS No.: 473-90-5

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vivo
Chemical Information
Purity & Documentation
References
Calculators
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Biological Activity

Description

In Vivo

Mesoxalate increases pancreatic insulin content in rats, puppies and adult dogs, but this effect attenuates following long-term administration in some animal models^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 473-90-5
Molecular Weight 118.04
Formula C₃H₂O₅
SMILES

O=C(C(C(O)=O)=O)O
Synonyms

Ketomalonic acid; Mesoxalic acid; Oxomalonic acid
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (267 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Bernatchez JA, et al. Derivatives of mesoxalic acid block translocation of HIV-1 reverse transcriptase. The Journal of biological chemistry. 2015 Jan 16;290(3):1474-84. [Content Brief]

[2]. Davis WR, et al. Inhibition of HIV-1 reverse transcriptase-catalyzed DNA strand transfer reactions by 4-chlorophenylhydrazone of mesoxalic acid. Biochemistry. 2000 Nov 21;39(46):14279-91. [Content Brief]

[3]. TAKEUCHI S. Effect of mesoxalate on insulin content of pancreas. Endocrinol Jpn. 1958 Sep;5(3):177-84. [Content Brief]

[4]. KOBAYASHI Y, et al. Mechanism of anti-diabetic activity of calcium mesoxalate[J]. The Japanese Journal of Pharmacology, 1955, 4(2): 103-110.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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