475-80-9
475-80-9
Chemical Structure
Aristolochic acid B
Synonym(s): Aristolochic acid II
- CAS No.: 475-80-9
- Formula:C16H9NO6
- Molecular Weight:311.25
IUPAC Name: 6-nitrophenanthro[3,4-d][1,3]dioxole-5-carboxylic acid
InChIKey: MEEXETVZNQYRSP-UHFFFAOYSA-N
SMILES: O=C(C1=C2C([N+]([O-])=O)=CC3=CC=CC=C3C2=C(OCO4)C4=C1)O
Biological Activity: Aristolochic acid B (Aristolochic Acid II) is an orally active major component of aristolochic acid (AA). Aristolochic acid B can be isolated from plants of the genus Aristolochica. Aristolochic acid B forms DNA adducts. Aristolochic acid B is mutagenic. Aristolochic acid B exhibits a greater carcinogenic risk in vivo than Aristolochic acid I (HY-N0510)[1][2][3].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Aristolochic acid B | 99.92% | Aristolochic acid B (Aristolochic Acid II) is an orally active major component of aristolochic acid (AA). Aristolochic acid B can be isolated from plants of the genus Aristolochica. Aristolochic acid B forms DNA adducts. Aristolochic acid B is mutagenic. Aristolochic acid B exhibits a greater carcinogenic risk in vivo than Aristolochic acid I (HY-N0510). | ||||||||||||||||||||
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Aristolochic acid B (Standard) | ≥98% | Aristolochic acid B (Standard) is the analytical standard of Aristolochic acid B (HY-N0511). This product is intended for research and analytical applications. Aristolochic acid B (Aristolochic Acid II) is an orally active major component of aristolochic acid (AA). Aristolochic acid B can be isolated from plants of the genus Aristolochica. Aristolochic acid B forms DNA adducts. Aristolochic acid B is mutagenic. Aristolochic acid B exhibits a greater carcinogenic risk in vivo than Aristolochic acid I (HY-N0510). | ||||||||||||||||||||
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Aristolochic acid A sodium | 99.93% | Aristolochic acid A (Aristolochic acid I) sodium is the main component of plant extract Aristolochic acids, which are found in various herbal plants of genus Aristolochia and Asarum. Aristolochic acid A sodium significantly reduces both activator protein 1 (AP-1) and NF-κB activities. Aristolochic acid A sodium reduces BLCAP gene expression in human cell lines. | ||||||||||||||||||||
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Aristolochic acid A (Standard) | ≥98% | Aristolochic acid A (Standard) is the analytical standard of Aristolochic acid A. This product is intended for research and analytical applications. Aristolochic acid A (Aristolochic acid I; TR 1736) is the main component of plant extract Aristolochic acids, which are found in various herbal plants of genus Aristolochia and Asarum. Aristolochic acid A significantly reduces both activator protein 1 (AP-1) and NF-κB activities. Aristolochic acid A reduces BLCAP gene expression in human cell lines. | ||||||||||||||||||||
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Aristolochic acid Va | 98.74% | Aristolochic acid Va is a natural compound that can be isolated from Aristolochia plants. | ||||||||||||||||||||
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Aristololactam II | 98.59% | Aristololactam II is an aristololactam-related blue-fluorescent compound found in the callus tissue of Stephania cepharantha. | ||||||||||||||||||||
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Aristolochic acid C (Standard) | ≥98% | Aristolochic acid C (Standard) is the analytical standard of Aristolochic acid C. This product is intended for research and analytical applications. Aristolochic acid C is a derivative of Aristolochic acid. Aristolochic acid is a phospholipase A2 (PLA2) inhibitor, which disrupts cortical microtubule arrays and root growth in Arabidopsis. | ||||||||||||||||||||
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Aristolochic acid D (Standard) | ≥98% | Aristolochic acid D (Standard) (Aristolochic acid-IVa (Standard)) is the analytical standard of Aristolochic acid D (HY-N1465). This product is intended for research and analytical applications. Aristolochic acid D (Aristolochic acid-IVa) is an orally active PDE2 (IC50: 4.673 μM) and CDK2 (IC50: 25 μM) inhibitor that can be isolated from Aristolochia indica L. Aristolochic acid D exhibits anti-inflammatory activity and is non-carcinogenic and non-nephrotoxic. Aristolochic acid D can be used in the research of inflammation and tumor-related diseases. | ||||||||||||||||||||
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Ariskanin A | Ariskanin A is a platelet aggregation inhibitor that exists in Aristolochia kankauensis and Aristolochia manshuriensis. Ariskanin A inhibits rabbit platelet aggregation. | |||||||||||||||||||||
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7-Hydroxyaristolochic acid A | 99.65% | 7-Hydroxyaristolochic acid A is an aristolochic acid analogue found in Aristolochia plants. Aristolochic acid can be used as an anti-inflammatory agent. | ||||||||||||||||||||
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Aristolochic acid III | 85.0% | Aristolochic acid III is a natural product that can be isolated from the leaves of Aristolochia debilis. | ||||||||||||||||||||
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Aristolochic acid Ia | Aristolochic acid Ia is an oxidative metabolite of aristolochic acid I, which can be used to study the detoxification pathway of aristolochic acid metabolism. | |||||||||||||||||||||
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References
- [1]. Xing G, et al. Comparison of the mutagenicity of aristolochic acid I and aristolochic acid II in the gpt delta transgenic mouse kidney. Mutat Res. 2012 Mar 18;743(1-2):52-8. [Content Brief]
- [2]. Yeh YH, et al. Short-term toxicity of aristolochic acid, aristolochic acid-I and aristolochic acid-II in rats. Food Chem Toxicol. 2008 Mar;46(3):1157-63. [Content Brief]
- [3]. Schmeiser HH, et al. DNA adduct formation of aristolochic acid I and II in vitro and in vivo. Carcinogenesis. 1988 Feb;9(2):297-303. [Content Brief]
