564462-36-8
564462-36-8
Chemical Structure
γ-secretase-IN-2
- CAS No.: 564462-36-8
- Formula:C31H24F3N3O3
- Molecular Weight:543.54
IUPAC Name: (2S,3R)-3-(3,4-difluorophenyl)-2-(4-fluorophenyl)-4-hydroxy-N-((S)-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)butanamide
InChIKey: JFRCHOZGXWZLOQ-TZIIFLTASA-N
SMILES: OC[C@@H](C1=CC(F)=C(F)C=C1)[C@@H](C2=CC=C(F)C=C2)C(N[C@H]3N=C(C4=CC=CC=C4)C5=CC=CC=C5NC3=O)=O
Biological Activity: γ-secretase-IN-2 (Compound 34) is an inhibitor for γ-secretase, with an IC50 of 0.06 nM. γ-secretase-IN-2 can be used for the study of Alzheimer's disease[1].
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γ-secretase-IN-2 | γ-secretase-IN-2 (Compound 34) is an inhibitor for γ-secretase, with an IC50 of 0.06 nM. γ-secretase-IN-2 can be used for the study of Alzheimer's disease. | |||||||||||||||||||||
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References
- [1]. Churcher I, et al., Design and synthesis of highly potent benzodiazepine gamma-secretase inhibitors: preparation of (2S,3R)-3-(3,4-difluorophenyl)-2-(4-fluorophenyl)-4- hydroxy-N-((3S)-1-methyl-2-oxo-5- phenyl-2,3-dihydro-1H-benzo[e][1,4]-diazepin-3-yl)butyramide by use of an asymmetric Ireland-Claisen rearrangement. J Med Chem. 2003 Jun 5;46(12):2275-8. [Content Brief]
Keywords
