γ-secretase-IN-2
γ-secretase-IN-2 (Compound 34) is an inhibitor for γ-secretase, with an IC50 of 0.06 nM. γ-secretase-IN-2 can be used for the study of Alzheimer's disease.
For research use only. We do not sell to patients.
- CAS No.: 564462-36-8
- Formula: C31H24F3N3O3
- Molecular Weight:543.54
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
IC50: 0.07 nM (γ-secretase)
Chemical Information
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CAS No. 564462-36-8
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Molecular Weight 543.54
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Formula C31H24F3N3O3
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SMILES
OC[C@@H](C1=CC(F)=C(F)C=C1)[C@@H](C2=CC=C(F)C=C2)C(N[C@H]3N=C(C4=CC=CC=C4)C5=CC=CC=C5NC3=O)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Churcher I, et al., Design and synthesis of highly potent benzodiazepine gamma-secretase inhibitors: preparation of (2S,3R)-3-(3,4-difluorophenyl)-2-(4-fluorophenyl)-4- hydroxy-N-((3S)-1-methyl-2-oxo-5- phenyl-2,3-dihydro-1H-benzo[e][1,4]-diazepin-3-yl)butyramide by use of an asymmetric Ireland-Claisen rearrangement. J Med Chem. 2003 Jun 5;46(12):2275-8. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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