γ-secretase-IN-2
γ-secretase-IN-2 (Compound 34) is an inhibitor for γ-secretase, with an IC50 of 0.06 nM. γ-secretase-IN-2 can be used for the study of Alzheimer's disease.
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- CAS No.: 564462-36-8
- Formule: C31H24F3N3O3
- Masse moléculaire:543.54
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
Description
IC50 & Target
IC50: 0.07 nM (γ-secretase)
Chemical Information
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CAS No. 564462-36-8
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Masse moléculaire 543.54
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Formule C31H24F3N3O3
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SMILES
OC[C@@H](C1=CC(F)=C(F)C=C1)[C@@H](C2=CC=C(F)C=C2)C(N[C@H]3N=C(C4=CC=CC=C4)C5=CC=CC=C5NC3=O)=O
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
[1]. Churcher I, et al., Design and synthesis of highly potent benzodiazepine gamma-secretase inhibitors: preparation of (2S,3R)-3-(3,4-difluorophenyl)-2-(4-fluorophenyl)-4- hydroxy-N-((3S)-1-methyl-2-oxo-5- phenyl-2,3-dihydro-1H-benzo[e][1,4]-diazepin-3-yl)butyramide by use of an asymmetric Ireland-Claisen rearrangement. J Med Chem. 2003 Jun 5;46(12):2275-8. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
γ-secretase-IN-2 Related Classifications
HY-117381 Related Classifications
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