57404-51-0
Chemical Structure
DA-11004
- CAS No.: 57404-51-0
- Formula:C11H9NO2
- Molecular Weight:187.20
IUPAC Name: 4-(methylamino)naphthalene-1,2-dione
InChIKey: BPGSNZXXCCSOAN-UHFFFAOYSA-N
SMILES: O=C1C=C(NC)C=2C=CC=CC2C1=O
Biological Activity: DA-11004 is an orally active NADP-dependent isocitrate dehydrogenase (IDPc) inhibitor with an IC50 of 1.49 μM. DA-11004 reduces NADPH production, decreases plasma NADPH levels and plasma free fatty acid levels. DA-11004 lowers plasma glucose levels, inhibits fatty acid synthesis in adipose tissue, reduces weight gain and decreases epididymal and retroperitoneal fat content. DA-11004 exerts antidiabetic effects in mice fed a high-fat and high-sugar diet. DA-11004 can be used for research on obesity and type 2 diabetes[1].
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DA-11004 | DA-11004 is an orally active NADP-dependent isocitrate dehydrogenase (IDPc) inhibitor with an IC50 of 1.49 μM. DA-11004 reduces NADPH production, decreases plasma NADPH levels and plasma free fatty acid levels. DA-11004 lowers plasma glucose levels, inhibits fatty acid synthesis in adipose tissue, reduces weight gain and decreases epididymal and retroperitoneal fat content. DA-11004 exerts antidiabetic effects in mice fed a high-fat and high-sugar diet. DA-11004 can be used for research on obesity and type 2 diabetes. | |||||||||||||||||||||
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