DA-11004
DA-11004 is an orally active NADP-dependent isocitrate dehydrogenase (IDPc) inhibitor with an IC50 of 1.49 μM. DA-11004 reduces NADPH production, decreases plasma NADPH levels and plasma free fatty acid levels. DA-11004 lowers plasma glucose levels, inhibits fatty acid synthesis in adipose tissue, reduces weight gain and decreases epididymal and retroperitoneal fat content. DA-11004 exerts antidiabetic effects in mice fed a high-fat and high-sugar diet. DA-11004 can be used for research on obesity and type 2 diabetes.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 57404-51-0
- 分子式: C11H9NO2
- 分子量:187.20
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
製品説明
IC50 & Target
[1]|
IDPc 1.49 μM (IC50) |
体内実験
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:C57BL/6J (male, diet-induced obesity model)[1]
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Dosage:30 mg/kg; 100 mg/kg
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Administration:p.o.; daily; 8 weeks
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Result:Reduced final body weight to 30.0 g, epididymal fat weight to 1.26 g, retroperitoneal fat weight to 0.65 g, plasma glucose level to 195.2 mg/dL, plasma triglyceride level to 75.1 mg/dL, plasma total cholesterol level to 99.1 mg/dL, and plasma free fatty acid level to 979 μEq/L at 30 mg/kg.
Reduced final body weight to 24.1 g, epididymal fat weight to 0.63 g, retroperitoneal fat weight to 0.30 g, plasma glucose level to 169.3 mg/dL, plasma triglyceride level to 63.2 mg/dL, plasma total cholesterol level to 105.4 mg/dL, and plasma free fatty acid level to 955 μEq/L at 100 mg/kg.
Dose-dependently inhibited plasma IDPc activity and reduced plasma NADPH levels, with the 100 mg/kg dose producing a greater effect.
化学情報
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CAS 番号 57404-51-0
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分子量 187.20
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分子式 C11H9NO2
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SMILES
O=C1C=C(NC)C=2C=CC=CC2C1=O
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
DA-11004 関連分類
HY-16164 関連分類
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