71876-60-3
Chemical Structure
Heliantriol C
- CAS No.: 71876-60-3
- Formula:C30H50O3
- Molecular Weight:458.73
IUPAC Name: (3S,4aR,6aR,6bR,8S,8aS,9S,12S,12aR,12bR,14aR,14bR)-4,4,6a,6b,8a,11,12,14b-octamethyl-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,12,12a,12b,13,14,14a,14b-icosahydropicene-3,8,9-triol
InChIKey: SCAPWGHHHZEERU-DTCGCZLXSA-N
SMILES: C[C@]12[C@@]([C@@]3([C@@](C)([C@@H](O)C1)[C@@H](O)C=C(C)[C@H]3C)[H])(CC[C@]4([C@@]2(C)CC[C@@]5([C@]4(C)CC[C@H](O)C5(C)C)[H])[H])[H]
Biological Activity: Heliantriol C is a taraxerane-type trihydroxy triterpenoid present in the ray florets of Asteraceae plants. Heliantriol C inhibits TPA (HY-18739)-induced inflammation. Heliantriol C exhibits anticancer activity, and its acetylated derivatives show enhanced cytotoxicity against cancer cells. Heliantriol C can be used in studies related to inflammation and cancers such as leukemia and lung cancer[1][2][3].
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Heliantriol C | Heliantriol C is a taraxerane-type trihydroxy triterpenoid present in the ray florets of Asteraceae plants. Heliantriol C inhibits TPA (HY-18739)-induced inflammation. Heliantriol C exhibits anticancer activity, and its acetylated derivatives show enhanced cytotoxicity against cancer cells. Heliantriol C can be used in studies related to inflammation and cancers such as leukemia and lung cancer. | |||||||||||||||||||||
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References
- [1]. Yasukawa K, et al. Inhibitory effect of Di- and trihydroxy triterpenes from the flowers of compositae on 12-O-tetradecanoylphorbol-13-acetate-induced inflammation in mice. Biological & pharmaceutical bulletin. 1996 Oct;19(10):1329-31. [Content Brief]
- [2]. Ukiya M, et al. Cytotoxic and Apoptosis‑inducing Activities of Taraxastane‑type Triterpenoid Derivatives in Human Cancer Cell Lines. Chemistry & Biodiversity, 2016, 13(8): 1018‑1029.
- [3]. Yasukawa K, et al. Inhibitory effect of heliantriol C; a component of edible Chrysanthemum, on tumor promotion by 12-O-tetradecanoylphorbol-13-acetate in two-stage carcinogenesis in mouse skin. Phytomedicine : international journal of phytotherapy and phytopharmacology. 1998 May;5(3):215-8. [Content Brief]
