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製品番号: HY-187045

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Heliantriol C

Heliantriol C is a taraxerane-type trihydroxy triterpenoid present in the ray florets of Asteraceae plants. Heliantriol C inhibits TPA (HY-18739)-induced inflammation. Heliantriol C exhibits anticancer activity, and its acetylated derivatives show enhanced cytotoxicity against cancer cells. Heliantriol C can be used in studies related to inflammation and cancers such as leukemia and lung cancer.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

CAS 番号: 71876-60-3
分子式: C₃₀H₅₀O₃
分子量:458.73

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (286 KB)

Heliantriol C 構造式

CAS 番号: 71876-60-3

価格（税別）

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

体外実験

Anti-cancerOthers

Anti-cancer

Heliantriol C (compound 3) (48 h) exhibits lower cytotoxicity against the human cancer cell lines HL60, A549, AZ521 and SK-BR-3 than dihydroxy taraxastane-type triterpenoids and their acetyl derivatives^[2].

Others

Heliantriol C undergoes acetylation with Ac₂O in pyridine to form heliantriol C 3,16,22-tri-O-acetate (compound 25); oxidation with MnO₂ in CHCl₃ yields 22-oxofaradiol (compound 26)^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

体内実験

OthersAnti-cancer

Others

Heliantriol C (compound 3) (0.03 mg/ear; local administration; single dose) potently inhibits TPA (HY-18739)-induced ear swelling in female ICR mice, with an ID₅₀ of 0.03 mg/ear^[1].

Anti-cancer

Heliantriol C (0.2 μmol per mouse; topical administration; administered 30 minutes before each TPA treatment, twice weekly, for 20 weeks) reduces the average number of skin tumors per mouse and decreases the proportion of tumor-bearing mice at week 20 in the DMBA/TPA two-stage mouse skin carcinogenesis model^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

ICR mice (female, 7 weeks old, two-stage skin tumorigenesis model initiated by DMBA, promoted by TPA)^[3]
Dosage:

0.2 μmol per mouse
Administration:

topical; 30 minutes before each twice-weekly TPA application; 20 weeks
Result:

Delayed initial skin tumor onset until week 13 (control: week 8).
Lowered tumor-bearing mouse ratio to 20% at week 20 (control: 93%).
Cut average tumor count per mouse to 0.9 at week 20 (control: 8.6).
Produced obvious disparities versus control starting at week 11.
Generated distinct differences versus faradiol group from week 16 to 20.

Related Protocols :

化学情報

CAS 番号 71876-60-3
分子量 458.73
分子式 C₃₀H₅₀O₃
SMILES

C[C@]12[C@@]([C@@]3([C@@](C)([C@@H](O)C1)[C@@H](O)C=C(C)[C@H]3C)[H])(CC[C@]4([C@@]2(C)CC[C@@]5([C@]4(C)CC[C@H](O)C5(C)C)[H])[H])[H]
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (286 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Yasukawa K, et al. Inhibitory effect of Di- and trihydroxy triterpenes from the flowers of compositae on 12-O-tetradecanoylphorbol-13-acetate-induced inflammation in mice. Biological & pharmaceutical bulletin. 1996 Oct;19(10):1329-31. [Content Brief]

[2]. Ukiya M, et al. Cytotoxic and Apoptosis‑inducing Activities of Taraxastane‑type Triterpenoid Derivatives in Human Cancer Cell Lines. Chemistry & Biodiversity, 2016, 13(8): 1018‑1029.

[3]. Yasukawa K, et al. Inhibitory effect of heliantriol C; a component of edible Chrysanthemum, on tumor promotion by 12-O-tetradecanoylphorbol-13-acetate in two-stage carcinogenesis in mouse skin. Phytomedicine : international journal of phytotherapy and phytopharmacology. 1998 May;5(3):215-8. [Content Brief]

Calculators

モル濃度計算機

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100 mg

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