81486-22-8
81486-22-8
Chemical Structure
Nipradolol
Synonym(s): KT 210; K 351; Hypadil
- CAS. Nr.: 81486-22-8
- Formula:C15H22N2O6
- Molecular Weight:326.34
IUPAC Name: 8-(2-hydroxy-3-(isopropylamino)propoxy)chroman-3-yl nitrate
InChIKey: OMCPLEZZPVJJIS-UHFFFAOYSA-N
SMILES: CC(C)NCC(O)COC1=C2C(CC(O[N+]([O-])=O)CO2)=CC=C1
Biological Activity: Nipradolol (KT-210; K-351) is a potent blocker of alpha-1-adrenergic receptors. Nipradolol inhibits the increase of intraocular pressure (IOP) in an albino rabbit model induced by Phenylephrine (HY-B0769). Nipradolo suppresses the noradrenaline (NA)-induced muscles contraction, also exhibits vasodilator activity on the dog coronary artery[1][2].
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Nipradolol | Nipradolol (KT-210; K-351) is a potent blocker of alpha-1-adrenergic receptors. Nipradolol inhibits the increase of intraocular pressure (IOP) in an albino rabbit model induced by Phenylephrine (HY-B0769). Nipradolo suppresses the noradrenaline (NA)-induced muscles contraction, also exhibits vasodilator activity on the dog coronary artery. | |||||||||||||||||||||
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References
- [1]. 3,4-dihydro-8-(2-hydroxy-3-isopropylaminopropoxy)-3-nitroxy-2H-1-benzopyran (K-351) and its denitrated derivative on smooth muscle cells of the dog coronary artery. Br J Pharmacol. 1983 May;79(1):285-95. [Content Brief]
- [2]. Nishio K. Alpha-1-adrenoceptor blocking activity of KT-210 (nipradilol ophthalmic solution) on intraocular pressure in the rabbit eye[J]. Nihon Ganka Kiyo (Folia Ophthalmol Jpn), 1999, 50: 655-660.
