824431-12-1
824431-12-1
Chemical Structure
AX-7396
Synonym(s): RGB-315389
- CAS No.: 824431-12-1
- Formula:C15H11Cl2N3
- Molecular Weight:304.17
InChIKey: ANWHPGDPFVPDRT-UHFFFAOYSA-N
SMILES: ClC1=CC=C(NC2=C3C=C(C)C=CC3=NC=N2)C=C1Cl
Biological Activity: AX-7396 (RGB-315389) is a pUL97 protein kinase inhibitor with an IC50 of 0.35 μM against HCMV pUL97 kinase. AX-7396 inhibits the replication of wild-type and agent-resistant HCMV, GPCMV, MCMV and RCMV in vitro, with the strongest potency against MCMV (IC50 1.6 μM). AX-7396 shows no significant antiviral activity in a mouse cytomegalovirus infection model. AX-7396 can be used in studies related to cytomegalovirus infection[1][2].
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AX-7396 | AX-7396 (RGB-315389) is a pUL97 protein kinase inhibitor with an IC50 of 0.35 μM against HCMV pUL97 kinase. AX-7396 inhibits the replication of wild-type and agent-resistant HCMV, GPCMV, MCMV and RCMV in vitro, with the strongest potency against MCMV (IC50 1.6 μM). AX-7396 shows no significant antiviral activity in a mouse cytomegalovirus infection model. AX-7396 can be used in studies related to cytomegalovirus infection. | |||||||||||||||||||||
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References
- [1]. Breza N, et al. Synthesis and characterization of novel quinazoline type inhibitors for mutant and wild-type EGFR and RICK kinases. Journal of receptor and signal transduction research. 2008;28(4):361-73. [Content Brief]
- [2]. Schleiss M, et al. Protein kinase inhibitors of the quinazoline class exert anti-cytomegaloviral activity in vitro and in vivo. Antiviral research. 2008 Jul;79(1):49-61. [Content Brief]
