879010-15-8
Chemical Structure
(RXR)4XB
- CAS No.: 879010-15-8
- Formula:C81H158N38O15
- Molecular Weight:1904.37
SMILES: N=C(N)NCCC[C@H](N)C(NCCCCCC(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCNC(N)=N)C(NCCCCCC(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCNC(N)=N)C(NCCCCCC(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCNC(N)=N)C(NCCCCCC(N[C@@H](CCCNC(N)=N)C(NCCCCCC(NCCC(O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O
Biological Activity: (RXR)4XB is a cell-penetrating peptide, that binds the phosphorodiamidate morpholino oligomers (PMOs), forms peptide-conjugated PMOs (PPMOs), and improves the delivery of PMO into bacterial cells. (RXR)4XB-PMO conjugate prevents the formation of biofilms, inhibits Pseudomonas aeruginosa with MIC50 of 0.5 to 16 μM, and reduces the bacterial burden in mouse acute pneumonia models[1].
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(RXR)4XB | (RXR)4XB is a cell-penetrating peptide, that binds the phosphorodiamidate morpholino oligomers (PMOs), forms peptide-conjugated PMOs (PPMOs), and improves the delivery of PMO into bacterial cells. (RXR)4XB-PMO conjugate prevents the formation of biofilms, inhibits Pseudomonas aeruginosa with MIC50 of 0.5 to 16 μM, and reduces the bacterial burden in mouse acute pneumonia models. | |||||||||||||||||||||
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Keywords
