946398-78-3
Chemical Structure
11β-HSD1-IN-15
- CAS No.: 946398-78-3
- Formula:C19H18ClF4N3O3S
- Molecular Weight:479.88
IUPAC Name: (R)-3-chloro-4-((4-(4-fluoro-2-(trifluoromethyl)phenyl)-2-methylpiperazin-1-yl)sulfonyl)benzamide
InChIKey: OMWNFYWEMXUREB-LLVKDONJSA-N
SMILES: FC(F)(C1=C(N2C[C@H](N(CC2)S(=O)(C3=C(C=C(C=C3)C(N)=O)Cl)=O)C)C=CC(F)=C1)F
Biological Activity: 11β-HSD1-IN-15 is an inhibitor of 11β-hydroxysteroid dehydrogenase type I (11β-HSD1). 11β-HSD1-IN-15 blocks the conversion of corticosterone to cortisol by binding to the active site of the 11β-HSD1 enzyme. 11β-HSD1-IN-15 can be used to investigate the role of 11β-HSD1 enzymes IN the development of metabolic syndrome, obesity, cognitive decline and type 2 diabetes[1].
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11β-HSD1-IN-15 | 11β-HSD1-IN-15 is an inhibitor of 11β-hydroxysteroid dehydrogenase type I (11β-HSD1). 11β-HSD1-IN-15 blocks the conversion of corticosterone to cortisol by binding to the active site of the 11β-HSD1 enzyme. 11β-HSD1-IN-15 can be used to investigate the role of 11β-HSD1 enzymes IN the development of metabolic syndrome, obesity, cognitive decline and type 2 diabetes. | |||||||||||||||||||||
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