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Cat. No.: HY-14156

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11β-HSD1-IN-15

11β-HSD1-IN-15 is an inhibitor of 11β-hydroxysteroid dehydrogenase type I (11β-HSD1). 11β-HSD1-IN-15 blocks the conversion of corticosterone to cortisol by binding to the active site of the 11β-HSD1 enzyme. 11β-HSD1-IN-15 can be used to investigate the role of 11β-HSD1 enzymes IN the development of metabolic syndrome, obesity, cognitive decline and type 2 diabetes.

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CAS No.: 946398-78-3
Formule: C₁₉H₁₈ClF₄N₃O₃S
Masse moléculaire:479.88

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (267 KB)

11β-HSD1-IN-15 Chemical Structure

CAS No.: 946398-78-3

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Activité biologique
- Description
- Cellular Effect
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
Bioz

Activité biologique

Description

Cellular Effect

Cell Line	Type	Value	Description	References
CHO	IC₅₀	0.01 μM Compound: 20	Inhibition of human 11betaHSD1 expressed in CHO cells Inhibition of human 11betaHSD1 expressed in CHO cells	[PMID: 19673466]
CHO	IC₅₀	0.01 μM Compound: 20	Inhibition of mouse 11betaHSD1 expressed in CHO cells Inhibition of mouse 11betaHSD1 expressed in CHO cells	[PMID: 19673466]
CHO	IC₅₀	0.01 μM Compound: 20	Inhibition of mouse 11betaHSD1 expressed in CHO cells in presence of 10 % (v/v) human serum Inhibition of mouse 11betaHSD1 expressed in CHO cells in presence of 10 % (v/v) human serum	[PMID: 19673466]

Chemical Information

CAS No. 946398-78-3
Masse moléculaire 479.88
Formule C₁₉H₁₈ClF₄N₃O₃S
SMILES

FC(F)(C1=C(N2C[C@H](N(CC2)S(=O)(C3=C(C=C(C=C3)C(N)=O)Cl)=O)C)C=CC(F)=C1)F
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (267 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Wan Z K, et al. Efficacious 11β-hydroxysteroid dehydrogenase type I inhibitors in the diet-induced obesity mouse model[J]. Journal of medicinal chemistry, 2009, 52(17): 5449-5461. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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