958226-81-8
Chemical Structure
Aurora kinase inhibitor-14
- CAS No.: 958226-81-8
- Formula:C28H38F3N7O2
- Molecular Weight:561.64
InChIKey: CIVZSIICMSDVMF-PZJWPPBQSA-N
SMILES: O=C(N(C)C1CCN(C)CC1)C2=CC=C(NC3=NC=C(C(F)(F)F)C(N[C@H]4C[C@@H](C(NC(C)C)=O)CC4)=N3)C=C2
Biological Activity: Aurora kinase inhibitor-14 (Compound 79) is an orally active and highly selective inhibitor of Aurora kinases with IC50 values of 0.5 nM and 1.2 nM for Aurora A and Aurora B, respectively. Aurora kinase inhibitor-14 binds to the ATP-binding site of Aurora kinases to block chromosome segregation during mitosis and induce apoptosis in tumor cells. Aurora kinase inhibitor-14 is promising for research of various solid tumors and hematological malignancies, such as non-small cell lung cancer, breast cancer, and acute myeloid leukemia[1].
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Aurora kinase inhibitor-14 | Aurora kinase inhibitor-14 (Compound 79) is an orally active and highly selective inhibitor of Aurora kinases with IC50 values of 0.5 nM and 1.2 nM for Aurora A and Aurora B, respectively. Aurora kinase inhibitor-14 binds to the ATP-binding site of Aurora kinases to block chromosome segregation during mitosis and induce apoptosis in tumor cells. Aurora kinase inhibitor-14 is promising for research of various solid tumors and hematological malignancies, such as non-small cell lung cancer, breast cancer, and acute myeloid leukemia. | |||||||||||||||||||||
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Keywords
