Aurora kinase inhibitor-14
Aurora kinase inhibitor-14 (Compound 79) is an orally active and highly selective inhibitor of Aurora kinases with IC50 values of 0.5 nM and 1.2 nM for Aurora A and Aurora B, respectively. Aurora kinase inhibitor-14 binds to the ATP-binding site of Aurora kinases to block chromosome segregation during mitosis and induce apoptosis in tumor cells. Aurora kinase inhibitor-14 is promising for research of various solid tumors and hematological malignancies, such as non-small cell lung cancer, breast cancer, and acute myeloid leukemia.
For research use only. We do not sell to patients.
- CAS No.: 958226-81-8
- Formula: C28H38F3N7O2
- Molecular Weight:561.64
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
All Aurora Kinase Isoforms
More
Biological Activity
Description
IC50 & Target
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Aurora A 0.5 nM (IC50) |
Aurora B 1.2 nM (IC50) |
Chemical Information
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CAS No. 958226-81-8
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Molecular Weight 561.64
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Formula C28H38F3N7O2
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SMILES
O=C(N(C)C1CCN(C)CC1)C2=CC=C(NC3=NC=C(C(F)(F)F)C(N[C@H]4C[C@@H](C(NC(C)C)=O)CC4)=N3)C=C2
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Aurora kinase inhibitor-14 Related Classifications
HY-158618 Related Classifications
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