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Art. -Nr.: HY-100291

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SX-3228

Name: SX-3228
Brand: MedChemExpress
SKU: HY-100291
Availability: PreOrder

2 Cited Publications

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Based on 2 publication(s) in Google Scholar

SX-3228 is a selective benzodiazepine1 (BZ1) receptor agonist with an IC₅₀ of 17 nM.

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

CAS. Nr.: 156364-04-4
Formel: C₁₈H₁₈N₄O₃
Molecular Weight:338.36

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (273 KB)

SX-3228 Chemical Structure

CAS. Nr.: 156364-04-4

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Publications (2)
Protokoll (1)
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

SX-3228 is a selective benzodiazepine1 (BZ1) receptor agonist with an IC₅₀ of 17 nM.

IC₅₀ & Target

IC50: 17 nM (BZ1 receptor)^[1]

In Vitro

SX-3228 is a selective ligand for the BZ1 receptor. Among the BZ-receptor subtypes, SX-3228 preferentially binds to the BZ1 receptor (IC₅₀=17 nM). It has very weak affinity for the BZ2 receptor (spinal cord: IC₅₀=127 nM), and virtually no affinity for the peripheral type BZ receptor (kidney: IC₅₀>10000 nM). A compound with similar selectivity, SX-3228 has been shown to bind to BZ receptors, but not to dopamine (D₁, D₂), serotonin (5-HT₁, 5-HT₂ and 5-HT₃ subtypes), noradrenaline (α₁, α₂, β), GABA or acetylcholine (muscarinic) subtypes^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.

In Vivo

Administration of 0.5-2.5 mg/kg SX-3228 to rats during the light phase induces a significant reduction of rapid-eye-movement sleep (REMS) (P<0.05) during the third recording hour. Administration of SX-3228 (0.5-2.5 mg/kg) at the beginning of the dark period significantly and dose-dependently reduces waking (W) and increases slow wave sleep (SWS) during the 6-h recording period (P<0.05-0.01); however, significant changes during the last recording hour are restricted to the 2.5 mg/kg dose (P<0.01)^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS. Nr. 156364-04-4
Molecular Weight 338.36
Formel C₁₈H₁₈N₄O₃
SMILES

O=C1NC2=C(CN(CC3=CC=CC=C3)CC2)C=C1C4=NN=C(OC)O4
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Publications (2)

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Journal Impact Factor

J Clin Med

Remimazolam and Its Place in the Current Landscape of Procedural Sedation and General Anesthesia. [Abstract]

2024 Jul 25;13(15):4362. PMID: 39124629
Preprints

2024 Jul 1.

Protokoll

All Cell Biology

Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (273 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Alvariño F, et al. Effect of SX-3228, a selective ligand for the BZ1 receptor, on sleep and waking during the light-dark cycle in the rat. Braz J Med Biol Res. 1999 Aug;32(8):1007-14. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Keywords

SX-3228

2 Cited Publications

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Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Publications (2)
Protokoll
Reinheit & Dokumentation
Verweise

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SX-3228

Publications Citing Use of MedChemExpress (MCE) SX-3228