BTK-IN-34
BTK-IN-34 (compound 9h) is a selective BTK inhibitor. BTK-IN-34 shows antiproliferative activity in RAMOS cells through selective inhibition of pBTK (Tyr223) without affecting Lyn and Syk, upstream proteins in the BCR signaling pathway.
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- CAS. Nr.: 3016419-52-3
- Formel: C22H29N3O4S
- Molecular Weight:431.55
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Chemical Information
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
Biologische Aktivität
BTK-IN-34 (compound 9h; 1-50 μM; 24 hours) decreases the pBTK, pERK 1/2 (Thr202/Tyr204), and p-p38 (Thr180/Tyr182) levels in RAMOS cells[1].
BTK-IN-34 (compound 9h) displays selective cytotoxicity against BTK-high RAMOS cells with an IC50 of 2.75 μM.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:RAMOS cells
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Concentration:1 μM, 10 μM, 50 μM
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Incubation Time:24 hours
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Result:Decreased pBTK (Tyr223) levels.
Chemical Information
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CAS. Nr. 3016419-52-3
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Molecular Weight 431.55
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Formel C22H29N3O4S
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SMILES
O=C1NC2=C(C=C(S(=O)(N3CCN(C(CCCC)=O)CC3)=O)C=C2)/C1=C4CCCC\4
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
BTK-IN-34 Related Classifications
HY-162257 Related Classifications
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