DOPE-PEG2000-LTLRWVGLMS

DOPE-PEG2000-LTLRWVGLMS: surface modification of liposomes and nanoparticles for tissue-targeted drug delivery, enabling selective drug accumulation in specific tissues identified by phage display screening.
Structural composition:
(1) DOPE; a phospholipid with two unsaturated oleoyl chains that anchors into lipid bilayers and provides fusogenic activity for endosomal escape;
(2) PEG2000; a hydrophilic polymer that creates a steric barrier reducing opsonization and RES clearance, prolonging circulation time;
(3) LTLRWVGLMS peptide; a tissue-targeting decapeptide identified by phage display that specifically recognizes and binds to receptors or surface markers on target tissue cells, directing nanocarriers to specific tissues for enhanced drug accumulation and therapeutic efficacy while reducing off-target effects on non-target tissues.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.