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Ddr1 - discoidin domain receptor family, member 1 Gene

Also Known as Cak; Nep; PTK3A; CD167a; 6030432F18

Species: Mus musculus

Gene Type: protein coding

Gene ID: 12305

About Ddr1

Chromosome 17: 35,992,459-36,015,513 reverse strand.GRCm39:CM001010.3

This gene has 12 transcripts (splice variants), 196 orthologues, 53 paralogues and is associated with 20 phenotypes. Ubiquitous expression in ovary adult (RPKM 32.9), colon adult (RPKM 31.1) and 24 other tissues.

Summary

Enables Collagen binding activity. Involved in several processes, including smooth muscle cell migration; smooth muscle cell-matrix adhesion; and wound healing, spreading of cells. Acts upstream of or within several processes, including collagen-activated tyrosine kinase receptor signaling pathway; mammary gland development; and neuron projection development. Located in plasma membrane. Is expressed in several structures, including central nervous system; future hindbrain; genitourinary system; mammary gland; and retina. Human ortholog(s) of this gene implicated in lung non-small cell carcinoma. Orthologous to human DDR1 (Discoidin Domain Receptor tyrosine kinase 1). [provided by Alliance of Genome Resources, Apr 2022]

Ddr1 Products (4)

mRNA	Protein	Name
NM_007584.3	NP_031610.1	epithelial discoidin domain-containing receptor 1 isoform 1 precursor
NM_172962.1	NP_766550.1	epithelial discoidin domain-containing receptor 1 isoform 2 precursor
NM_001198833.1	NP_001185762.1	epithelial discoidin domain-containing receptor 1 isoform 1 precursor
NM_001198831.1	NP_001185760.1	epithelial discoidin domain-containing receptor 1 isoform 1 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Verweise	Source
enables collagen binding	IDA IDA: Inferred from direct assay	16806867	MGI
enables collagen binding	IMP IMP: Inferred from mutant phenotype	12065315	MGI

Biological Process GO Annotation	Evidence	Verweise	Source
acts upstream of or within axon development	IMP IMP: Inferred from mutant phenotype	10970885	MGI
acts upstream of or within branching involved in mammary gland duct morphogenesis	IMP IMP: Inferred from mutant phenotype	11283268	MGI
acts upstream of cell population proliferation	IMP IMP: Inferred from mutant phenotype	12397034	MGI
acts upstream of or within collagen-activated tyrosine kinase receptor signaling pathway	IDA IDA: Inferred from direct assay	10970885	MGI
involved in collagen-activated tyrosine kinase receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	12065315	MGI
acts upstream of or within ear development	IMP IMP: Inferred from mutant phenotype	11283268	MGI
acts upstream of or within embryo implantation	IMP IMP: Inferred from mutant phenotype	11283268	MGI
acts upstream of or within mammary gland alveolus development	IMP IMP: Inferred from mutant phenotype	11283268	MGI
acts upstream of or within negative regulation of cell population proliferation	IMP IMP: Inferred from mutant phenotype	12397034	MGI
acts upstream of or within neuron projection extension	IMP IMP: Inferred from mutant phenotype	10970885	MGI
acts upstream of or within peptidyl-tyrosine autophosphorylation	IDA IDA: Inferred from direct assay	10970885	MGI
acts upstream of or within peptidyl-tyrosine phosphorylation	IDA IDA: Inferred from direct assay	12397034	MGI
acts upstream of or within protein autophosphorylation	IDA IDA: Inferred from direct assay	10970885	MGI
acts upstream of or within regulation of cell growth	IMP IMP: Inferred from mutant phenotype	12397034	MGI
acts upstream of or within regulation of cell-matrix adhesion	IMP IMP: Inferred from mutant phenotype	12397034	MGI
involved in regulation of extracellular matrix disassembly	IMP IMP: Inferred from mutant phenotype	12065315	MGI
involved in smooth muscle cell migration	IMP IMP: Inferred from mutant phenotype	12065315	MGI
involved in smooth muscle cell-matrix adhesion	IMP IMP: Inferred from mutant phenotype	12065315	MGI
involved in wound healing, spreading of cells	IMP IMP: Inferred from mutant phenotype	12065315	MGI

Cellular Component GO Annotation	Evidence	Verweise	Source
located in plasma membrane	IDA IDA: Inferred from direct assay	12397034	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Ddr1 Protein Structure

FA58C

PKc_like

0
200
400
600
800
911 a.a.

Protein Preferred Names	Protein Names
epithelial discoidin domain-containing receptor 1	CD167 antigen-like family member A cell adhesion kinase discoidin receptor tyrosine kinase epithelial discoidin domain receptor 1 protein-tyrosine kinase MPK-6 tyrosine kinase DDR tyrosine-protein kinase CAK

Recombinant Ddr1 Proteins

Art. -Nr.	Produktname	Accession	Reinheit
HY-P75301	DDR1 Protein, Mouse (Active, sf9, His-GST)	Q03146-2 (L444-V874)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P75302	DDR1 Protein, Mouse (HEK293, His, solution)	Q03146-2 (D20-T414)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P75303	DDR1 Protein, Mouse (HEK293, Fc)	Q03146-2 (M1-T414)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P77639	DDR1 Protein, Mouse (HEK293, His)	Q03146-2 (D20-T414)	≥ 95%, as determined by Bis-Tris PAGE.

Related Agents

Clinical Phase
Pre-clinical Phase

Clinical Phase

Bioactive Molecules (3)

Art. -Nr.	Produktname	Wirkung	Reinheit	Phase
HY-16961	Sitravatinib	Inhibitor	99.57%	Phase 3
HY-16961A	Sitravatinib malate	Inhibitor	/	Phase 3
HY-157442	GLPG3312	Inhibitor	98.63%	Phase 1

Pre-clinical Phase

Bioactive Molecules (17)

Art. -Nr.	Produktname	Wirkung	Reinheit	Rare Diseases
HY-135401	VU6015929	Inhibitor	99.50%	Unkown
HY-114173	DDR1-IN-4	Inhibitor	98.19%	Unkown
HY-NP175	Collagen (bovine skin)	Ligand	/	Unkown
HY-133670	DDR1-IN-6	Inhibitor	98.02%	Unkown
HY-156552	DDR1/2 inhibitor-2	Inhibitor	99.73%	Unkown
HY-13979A	DDR1-IN-1 dihydrochloride	Inhibitor	98.92%	Unkown
HY-133669	DDR1-IN-5	Inhibitor	99.65%	Unkown
HY-176184	PROTAC DDR1 degrader-1	Degrader	98.69%	Unkown
HY-167208	SR-302	Inhibitor	98.51%	Unkown
HY-183068	AP4-43	Inhibitor	/	Unkown
HY-176185	DDR1 ligand 1		/	Unkown
HY-175281	SJ11646	Degrader	/	Unkown
HY-179535	Axl-IN-21	Inhibitor	/	Unkown
HY-173284	DDR1-IN-11	Inhibitor	/	Unkown
HY-181839	DDR1/2 IN-4	Inhibitor	/	Unkown
HY-122848	DDR1/2 inhibitor-3	Inhibitor	/	Unkown
HY-162102	DDR1-IN-8	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Ddr1	NCBI	NCBI:780
Rattus norvegicus	Ddr1	NCBI	NCBI:25678