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Myod1 - myogenic differentiation 1 Gene

Also Known as MYF3; MyoD; Myod-1; bHLHc1

Species: Mus musculus

Gene Type: protein coding

Gene ID: 17927

Summary

Enables several functions, including DNA binding activity; DNA-binding transcription activator activity, RNA polymerase II-specific; and promoter-specific chromatin binding activity. Contributes to DNA binding activity. Involved in several processes, including cellular response to estradiol stimulus; histone acetylation; and positive regulation of snRNA transcription by RNA polymerase II. Acts upstream of or within several processes, including myotube differentiation; regulation of RNA metabolic process; and skeletal muscle fiber adaptation. Located in euchromatin; myofibril; and nucleus. Part of transcription regulator complex. Is expressed in several structures, including alimentary system; embryo mesenchyme; limb; limb bud; and musculature. Orthologous to human MYOD1 (myogenic differentiation 1). [provided by Alliance of Genome Resources, Apr 2022]

Myod1 Products (1)

mRNA	Protein	Name
NM_010866.2	NP_034996.2	myoblast determination protein 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Verweise	Source
contributes to DNA binding	IDA IDA: Inferred from direct assay	2503252	MGI
enables DNA-binding transcription activator activity	IDA IDA: Inferred from direct assay	15706034	MGI
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	10652346	MGI
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IMP IMP: Inferred from mutant phenotype	15890200	MGI
enables DNA-binding transcription factor activity	IDA IDA: Inferred from direct assay	12037670	MGI
enables DNA-binding transcription factor activity	IMP IMP: Inferred from mutant phenotype	26658965	MGI
enables E-box binding	IDA IDA: Inferred from direct assay	10652346	MGI
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	11714687	MGI
enables RNA polymerase II-specific DNA-binding transcription factor binding	IPI IPI: Inferred from physical interaction	10652346	MGI
enables bHLH transcription factor binding	IPI IPI: Inferred from physical interaction	2503252	MGI
enables chromatin DNA binding	IDA IDA: Inferred from direct assay	25085416	MGI
enables chromatin binding	IDA IDA: Inferred from direct assay	16245309	MGI
enables cis-regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	12486129	MGI
enables enzyme binding	IPI IPI: Inferred from physical interaction	20833138	MGI
enables promoter-specific chromatin binding	IDA IDA: Inferred from direct assay	25217815	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	7973707	MGI
enables protein homodimerization activity	IPI IPI: Inferred from physical interaction	10652346	MGI
enables sequence-specific DNA binding	IDA IDA: Inferred from direct assay	22638570	MGI
enables transcription factor binding	IPI IPI: Inferred from physical interaction	22638570	MGI
enables ubiquitin protein ligase binding	IPI IPI: Inferred from physical interaction	19319192	MGI

Biological Process GO Annotation	Evidence	Verweise	Source
involved in cellular response to estradiol stimulus	IDA IDA: Inferred from direct assay	15706034	MGI
acts upstream of or within cellular response to glucocorticoid stimulus	IDA IDA: Inferred from direct assay	19319192	MGI
acts upstream of or within cellular response to oxygen levels	IDA IDA: Inferred from direct assay	19319192	MGI
acts upstream of or within cellular response to starvation	IDA IDA: Inferred from direct assay	19319192	MGI
acts upstream of or within cellular response to tumor necrosis factor	IDA IDA: Inferred from direct assay	24349514	MGI
involved in muscle cell differentiation	IDA IDA: Inferred from direct assay	15706034	MGI
acts upstream of or within muscle organ development	IDA IDA: Inferred from direct assay	15192231	MGI
acts upstream of or within muscle organ development	IGI IGI: Inferred from genetic interaction	15634692	MGI
acts upstream of or within myoblast differentiation	IDA IDA: Inferred from direct assay	12037571	MGI
acts upstream of or within myoblast fate determination	IDA IDA: Inferred from direct assay	12486129	MGI
acts upstream of or within myoblast fusion	IMP IMP: Inferred from mutant phenotype	15890200	MGI
acts upstream of or within myotube differentiation	IDA IDA: Inferred from direct assay	9234731	MGI
acts upstream of or within myotube differentiation involved in skeletal muscle regeneration	IMP IMP: Inferred from mutant phenotype	1348494	MGI
involved in negative regulation of chromatin binding	IDA IDA: Inferred from direct assay	26658965	MGI
involved in negative regulation of chromatin binding	IMP IMP: Inferred from mutant phenotype	26658965	MGI
acts upstream of or within negative regulation of myoblast proliferation	IMP IMP: Inferred from mutant phenotype	15890200	MGI
acts upstream of or within positive regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	12782625	MGI
involved in positive regulation of binding	IDA IDA: Inferred from direct assay	26658965	MGI
involved in positive regulation of binding	IMP IMP: Inferred from mutant phenotype	26658965	MGI
involved in positive regulation of muscle cell differentiation	IDA IDA: Inferred from direct assay	16901893	MGI
acts upstream of or within positive regulation of skeletal muscle tissue regeneration	IMP IMP: Inferred from mutant phenotype	17028574	MGI
involved in positive regulation of snRNA transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	25217815	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	7659522	MGI
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	10652346	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IGI IGI: Inferred from genetic interaction	15572127	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	22638570	MGI
involved in positive regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	26658965	MGI
acts upstream of or within regulation of alternative mRNA splicing, via spliceosome	IDA IDA: Inferred from direct assay	9525963	MGI
acts upstream of or within regulation of alternative mRNA splicing, via spliceosome	IMP IMP: Inferred from mutant phenotype	9525963	MGI
involved in regulation of gene expression	IDA IDA: Inferred from direct assay	22740650	MGI
acts upstream of or within regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	19796622	MGI
involved in skeletal muscle cell differentiation	IDA IDA: Inferred from direct assay	26658965	MGI
acts upstream of or within skeletal muscle cell differentiation	IMP IMP: Inferred from mutant phenotype	22147266	MGI
involved in skeletal muscle cell differentiation	IMP IMP: Inferred from mutant phenotype	26658965	MGI
acts upstream of or within skeletal muscle fiber adaptation	IMP IMP: Inferred from mutant phenotype	19319192	MGI
acts upstream of or within skeletal muscle fiber development	IMP IMP: Inferred from mutant phenotype	19319192	MGI
acts upstream of or within skeletal muscle tissue development	IDA IDA: Inferred from direct assay	12037571	MGI
acts upstream of or within skeletal muscle tissue development	IGI IGI: Inferred from genetic interaction	8269513	MGI
acts upstream of or within skeletal muscle tissue development	IMP IMP: Inferred from mutant phenotype	19531352	MGI
involved in skeletal muscle tissue regeneration	IDA IDA: Inferred from direct assay	26658965	MGI
acts upstream of skeletal muscle tissue regeneration	IMP IMP: Inferred from mutant phenotype	17028574	MGI
involved in skeletal muscle tissue regeneration	IMP IMP: Inferred from mutant phenotype	26658965	MGI
acts upstream of or within striated muscle cell differentiation	IMP IMP: Inferred from mutant phenotype	17028574	MGI
acts upstream of transcription by RNA polymerase II	IGI IGI: Inferred from genetic interaction	24301466	MGI

Cellular Component GO Annotation	Evidence	Verweise	Source
located in chromatin	IDA IDA: Inferred from direct assay	20833138	MGI
located in cytoplasm	IDA IDA: Inferred from direct assay	19319192	MGI
located in euchromatin	IDA IDA: Inferred from direct assay	10652346	MGI
located in myofibril	IDA IDA: Inferred from direct assay	19319192	MGI
is active in nucleus	IDA IDA: Inferred from direct assay	26658965	MGI
located in nucleus	IDA IDA: Inferred from direct assay	11711431	MGI
part of transcription regulator complex	IDA IDA: Inferred from direct assay	2503252	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
myoblast determination protein 1

Myod1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Verweise
Intra	Myod1	P10085	Suv39h1	Mus musculus	O54864	Transcription Compl	16858404
Cross	Myod1	P10085	DDX5	Homo sapiens	P17844	Pull Down	17011493
Cross	Myod1	P10085	DDX5	Homo sapiens	P17844	Anti Tag CoIP	17011493
Cross	Myod1	P10085	KAT5	Homo sapiens	Q92993	Anti Tag CoIP	21936881
Cross	Myod1	P10085	KAT5	Homo sapiens	Q92993	Pull Down	21936881
Intra	Myod1	P10085	Smarcd3	Mus musculus	Q6P9Z1	Y2H	22068056
Intra	Myod1	P10085	Smarcd3	Mus musculus	Q6P9Z1	Anti Bait CoIP	22068056
Intra	Myod1	P10085	Smarcd3	Mus musculus	Q6P9Z1	Pull Down	22068056

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Art. -Nr.	Produktname	Wirkung	Reinheit	Rare Diseases
HY-112056	DIM-C-pPhCO2Me		99.47%	Unkown
HY-RS08957	MYOD1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-174575	Human MYOD1 mRNA		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Myod1	NCBI	NCBI:4654