Art. -Nr.: HY-119500

Ilimaquinone

2 Cited Publications

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Ilimaquinone, a marine sponge metabolite, displays anticancer activity via GADD153-mediated pathway. Ilimaquinone can induce vesiculation of the Golgi apparatus. Ilimaquinone exerts anti-HIV, anti-microbial, anti-inflammatory, and effects.

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Reinheit: 98.0%
CAS. Nr.: 71678-03-0
Formel: C₂₂H₃₀O₄
Molecular Weight:358.47

Speicherung:

Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month

Ilimaquinone Chemical Structure

CAS. Nr.: 71678-03-0

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Biologische Aktivität
- Beschreibung
- Cellular Effect
- In Vitro
- In Vivo
Chemical Information
Publications (2)
Lösungsmittel & Löslichkeit
- In Vitro
Reinheit & Dokumentation
Verweise
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

Ilimaquinone, a marine sponge metabolite, displays anticancer activity via GADD153-mediated pathway. Ilimaquinone can induce vesiculation of the Golgi apparatus^[1]. Ilimaquinone exerts anti-HIV, anti-microbial, anti-inflammatory, and effects^[2].

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Cellular Effect

Cell Line	Type	Value	Description	References
A2780	IC₅₀	10.9 μM Compound: 3	Cytotoxicity against human A2780 cells Cytotoxicity against human A2780 cells	[PMID: 15497946]
A549	IC₅₀	0.4 μg/mL Compound: 4	Cytotoxicity against human A549 cells after 6 days by MTT assay Cytotoxicity against human A549 cells after 6 days by MTT assay	[PMID: 9051909]
A549	IC₅₀	5.9 μM Compound: 14	Cytotoxicity against human A549 cells assessed as decrease in cell viability after 72 hrs by WST8 assay Cytotoxicity against human A549 cells assessed as decrease in cell viability after 72 hrs by WST8 assay	[PMID: 28558970]
BV-2	IC₅₀	10.4 μM Compound: 7	Antiinflammatory activity in mouse BV2 cells assessed as inhibition of LPS-stimulated nitric oxide production by Griess assay Antiinflammatory activity in mouse BV2 cells assessed as inhibition of LPS-stimulated nitric oxide production by Griess assay	[PMID: 28262525]
CHO-K1	GI₅₀	2 μM Compound: 1	Cytotoxicity against human CHOK1 cells after 48 hrs by SRB assay Cytotoxicity against human CHOK1 cells after 48 hrs by SRB assay	[PMID: 21155589]
HeLa	IC₅₀	>10 μM Compound: 1	Antiproliferative activity against human HeLa cells assessed as reduction in cell viability after 72 hrs by sulforhodamine B assay Antiproliferative activity against human HeLa cells assessed as reduction in cell viability after 72 hrs by sulforhodamine B assay	[PMID: 32040314]
HeLa	IC₅₀	7.6 μM Compound: 14	Cytotoxicity against human HeLa cells assessed as decrease in cell viability after 72 hrs by WST8 assay Cytotoxicity against human HeLa cells assessed as decrease in cell viability after 72 hrs by WST8 assay	[PMID: 28558970]
HT-29	GI₅₀	5.4 μM Compound: 1	Cytotoxicity against human HT-29 cells after 48 hrs by SRB assay Cytotoxicity against human HT-29 cells after 48 hrs by SRB assay	[PMID: 21155589]
MCF7	GI₅₀	3.9 μM Compound: 1	Cytotoxicity against human MCF7 cells after 48 hrs by SRB assay Cytotoxicity against human MCF7 cells after 48 hrs by SRB assay	[PMID: 21155589]
MCF7	IC₅₀	>10 μM Compound: 1	Antiproliferative activity against human MCF7 cells assessed as reduction in cell viability after 72 hrs by sulforhodamine B assay Antiproliferative activity against human MCF7 cells assessed as reduction in cell viability after 72 hrs by sulforhodamine B assay	[PMID: 32040314]
MCF7	IC₅₀	8.3 μM Compound: 14	Cytotoxicity against human MCF7 cells assessed as decrease in cell viability after 72 hrs by WST8 assay Cytotoxicity against human MCF7 cells assessed as decrease in cell viability after 72 hrs by WST8 assay	[PMID: 28558970]
NCI-H460	GI₅₀	1.8 μM Compound: 1	Cytotoxicity against human H460 cells after 48 hrs by SRB assay Cytotoxicity against human H460 cells after 48 hrs by SRB assay	[PMID: 21155589]
P388	IC₅₀	0.2 μg/mL Compound: 4	Cytotoxicity against mouse P388 cells after 3 days by MTT assay Cytotoxicity against mouse P388 cells after 3 days by MTT assay	[PMID: 9051909]
PC-3	IC₅₀	>10 μM Compound: 1	Antiproliferative activity against human PC3 cells assessed as reduction in cell viability by MTT assay Antiproliferative activity against human PC3 cells assessed as reduction in cell viability by MTT assay	[PMID: 32040314]
SF-268	GI₅₀	2.7 μM Compound: 1	Cytotoxicity against human SF268 cells after 48 hrs by SRB assay Cytotoxicity against human SF268 cells after 48 hrs by SRB assay	[PMID: 21155589]
WI-38	IC₅₀	9.7 μM Compound: 14	Cytotoxicity against human WI38 cells assessed as decrease in cell viability after 72 hrs by WST8 assay Cytotoxicity against human WI38 cells assessed as decrease in cell viability after 72 hrs by WST8 assay	[PMID: 28558970]

In Vitro

Ilimaquinone induces a concentration-dependent anti-proliferative effect in several types of cancer cell lines, including prostate cancer PC-3 and LNCaP, non-small cell lung cancer A549 and hepatocellular carcinoma Hep3B cells. Ilimaquinone (0.3-30 μM ; 48 hours) inhibits the proliferation of PC-3 cells, DU145, LNCaP, MG63, A549, Hep3B cells with GI₅₀s of 2.6 μM, 5.8, 4.6, 4.9, 4.1, 12.0μM, respectively^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[1]

Cell Line:

Prostate cancer PC-3 cells
Concentration:

0.3, 1, 3, 10, and 30 μM
Incubation Time:

48 hours
Result:

Inhibited the proliferation of PC-3 cells in a concentration-dependent manner.

In Vivo

Ilimaquinone exhibits terminal elimination half-lives (T_1/2=1.2±0.3 h) due to high plasma clearance (2.95±0.53 L/h/kg) following oral administration (10 mg/kg) in male Sprague-Dawley rats^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS. Nr. 71678-03-0
Appearance Solid
Molecular Weight 358.47
Formel C₂₂H₃₀O₄
Color Light yellow to brown
SMILES

C=C1[C@]2(CC[C@@H]([C@](C)([C@@]2(CCC1)[H])CC3=C(C(C=C(C3=O)OC)=O)O)C)C
Structure Classification
- Quinones
- Benzene Quinones
Initial Source
- Marine natural products
- Sponge
- Animals
marine sponge Halichondria sp.
Versand

Room temperature in continental US; may vary elsewhere.

Speicherung

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Publications (2)

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Journal Impact Factor

Proc Natl Acad Sci U S A

Monensin suppresses EMT-driven cancer cell motility by inducing Golgi pH-dependent exocytosis of GOLIM4. [Abstract]

2025 Jul 15;122(28):e2501347122. PMID: 40632561
bioRxiv

2026 Feb 25.

Lösungsmittel & Löslichkeit

In Vitro:

DMSO : 25 mg/mL (69.74 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

2.7896 mL

13.9482 mL

27.8963 mL

5 mM

0.5579 mL

2.7896 mL

5.5793 mL

10 mM

0.2790 mL

1.3948 mL

2.7896 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (277 KB)
SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Pin-Hsuan Lu, et al. Ilimaquinone, a Marine Sponge Metabolite, Displays Anticancer Activity via GADD153-mediated Pathway. Eur J Pharmacol. 2007 Feb 5;556(1-3):45-54. [Content Brief]

[2]. Heebin Son, et al. Stereo-Selective Pharmacokinetics of Ilimaquinone Epimers Extracted From a Marine Sponge in Rats. Mar Drugs. 2019 Mar 17;17(3):171. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	2.7896 mL	13.9482 mL	27.8963 mL	69.7408 mL
	5 mM	0.5579 mL	2.7896 mL	5.5793 mL	13.9482 mL
	10 mM	0.2790 mL	1.3948 mL	2.7896 mL	6.9741 mL
	15 mM	0.1860 mL	0.9299 mL	1.8598 mL	4.6494 mL
	20 mM	0.1395 mL	0.6974 mL	1.3948 mL	3.4870 mL
	25 mM	0.1116 mL	0.5579 mL	1.1159 mL	2.7896 mL
	30 mM	0.0930 mL	0.4649 mL	0.9299 mL	2.3247 mL
	40 mM	0.0697 mL	0.3487 mL	0.6974 mL	1.7435 mL
	50 mM	0.0558 mL	0.2790 mL	0.5579 mL	1.3948 mL
	60 mM	0.0465 mL	0.2325 mL	0.4649 mL	1.1623 mL

Keywords

Ilimaquinone

2 Cited Publications

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Ilimaquinone

Publications Citing Use of MedChemExpress (MCE) Ilimaquinone

Alle HIV Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Publications (2)

Lösungsmittel & Löslichkeit

Reinheit & Dokumentation

Verweise

Help & FAQs

Complete Stock Solution Preparation Table

Ilimaquinone Related Classifications

HY-119500 Related Classifications