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Art. -Nr.: HY-189095

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KLK6-IN-2

KLK6-IN-2 is a reversible non-covalent and selective KLK6 inhibitor, with an IC₅₀ of 2.1 μM against hKLK6. KLK6-IN-2 acts as a reversible competitive inhibitor of boar Spermatozoa acrosin, with a K_i of 2.6 μM against porcine acrosin. KLK6-IN-2 exhibits trypanocidal activity against Trypanosoma brucei rhodesiense, with an IC₅₀ of 3.71 μM.

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CAS. Nr.: 57323-76-9
Formel: C₁₄H₁₄N₂O
Molecular Weight:226.27

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

KLK6-IN-2 Chemical Structure

CAS. Nr.: 57323-76-9

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
Chemical Information
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Calculators
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Biologische Aktivität

Beschreibung

IC₅₀ & Target

^[1]

Trypanosoma

KLK6

2.1 μM (IC₅₀)

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In Vitro

KLK6-IN-2 (Compound 69) (range of concentrations; 15 min) acts as a reversible, competitive inhibitor of recombinant human KLK6 with an IC₅₀ of 2.1 μM, a ligand efficiency of 0.43, and a K_i of 7.5 μM^[1].
KLK6-IN-2 shows a favorable selectivity window for KLK6 over most tested kallikreins and trypsin-like serine proteases, with ~4- to ~9-fold selectivity relative to KLK5, KLK14, plasmin, and matriptase, but similar potency toward trypsin 3^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS. Nr. 57323-76-9
Molecular Weight 226.27
Formel C₁₄H₁₄N₂O
SMILES

NC(C1=CC=C(COC2=CC=CC=C2)C=C1)=N
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Handling Instructions (2659 KB)

Verweise

[1]. de Freitas R , et al. Fragment-Based Discovery of KLK6 and KLK7 Inhibitors[J]. Journal of Chemical Information and Modeling, 2026.

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

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100 mg

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KLK6-IN-2

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KLK6-IN-2 Related Classifications

HY-189095 Related Classifications

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