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Art. -Nr.: HY-178128

PSEN1-IN-3

PSEN1-IN-3 is a modulator of Gamma secretase complex.

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Please store the product under the recommended conditions in the Certificate of Analysis.

CAS. Nr.: 1093975-58-6

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität

Beschreibung

PSEN1-IN-3 is a modulator of Gamma secretase complex.

Cellular Effect

Cell Line	Type	Value	Description	References
CHO	EC₅₀	13 μM Compound: 3	Inhibition of human ERG expressed in CHO cells by patch clamp assay Inhibition of human ERG expressed in CHO cells by patch clamp assay	[PMID: 26142947]
HeLa	IC₅₀	35 μM Compound: 3	Inhibition of gamma-secretase-mediated notch processing in human HeLa cells assessed as NICD level by split-luciferase reporter assay Inhibition of gamma-secretase-mediated notch processing in human HeLa cells assessed as NICD level by split-luciferase reporter assay	[PMID: 26142947]
SH-SY5Y	IC₅₀	130 nM Compound: 3	Modulation of gamma-secretase in human SH-SY5Y cells overexpressing APP C-terminal fragment SPA4CT assessed as inhibition of intracellular amyloid beta 40 production by electrochemiluminescent assay Modulation of gamma-secretase in human SH-SY5Y cells overexpressing APP C-terminal fragment SPA4CT assessed as inhibition of intracellular amyloid beta 40 production by electrochemiluminescent assay	[PMID: 26142947]
SH-SY5Y	IC₅₀	31 nM Compound: 3	Modulation of gamma-secretase in human SH-SY5Y cells overexpressing APP C-terminal fragment SPA4CT assessed as inhibition of intracellular amyloid beta 42 production by electrochemiluminescent assay Modulation of gamma-secretase in human SH-SY5Y cells overexpressing APP C-terminal fragment SPA4CT assessed as inhibition of intracellular amyloid beta 42 production by electrochemiluminescent assay	[PMID: 26142947]

CAS. Nr. 1093975-58-6
Molecular Weight 514.47
Formel C₂₅H₂₂F₄N₆O₂
SMILES

COC1=CC(C2=CN([C@H]3CCC(C(F)=CC=C4)=C4N(CC(F)(F)F)C3=O)N=N2)=CC=C1N5C=NC(C)=C5
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.