Purpurides B and C, two new sesquiterpene esters from the aciduric fungus Penicillium purpurogenum JS03-21

  • Chem Biodivers. 2013 Jul;10(7):1185-92. doi: 10.1002/cbdv.201200175.
Hui Wang  1 ,  Yi Wang ,  Peipei Liu ,  Wei Wang ,  Yaqin Fan ,  Weiming Zhu
Affiliations
  • 1. Key Laboratory of Marine Drugs, Ministry of Education of China, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, P. R. China.
PMID: 23847064 DOI: 10.1002/cbdv.201200175
Abstract

Purpurides B and C (1 and 2, resp.), two new sesquiterpene alcohol esters generated from a drimane-type sesquiterpenoid lactone and an amino acid, together with two known analogs, berkedrimane B (3) and purpuride (4), were isolated from the aciduric fungus Penicillium purpurogenum JS03-21. Their structures were elucidated by spectroscopic analysis, X-ray single-crystal diffraction, and application of Marfey's method. Compounds 1-4 showed modest Antifungal activities against Candida albicans with MIC values in the range of 1.2-3.3 μM. Compounds 1 and 2 showed moderate antimicrobial activities against Enterobacter aerogenes and Pseudomonas aeruginosa with MIC values in the range of 1.2-2.6 μM.

Keywords
Antimicrobial activity; Fungi; Penicillium purpurogenum; Purpurides B and C; Sesquiterpenes.
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