Tumor-Intrinsic Kinome Landscape of Pancreatic Cancer Reveals New Therapeutic Approaches

  • Cancer Discov. 2025 Feb 7;15(2):346-362. doi: 10.1158/2159-8290.CD-23-1480.
Yi Xu  #  1  2 ,  Xianlu L Peng  #  1  2 ,  Michael P East  1 ,  Ian C McCabe  2  3 ,  Grace C Stroman  1  2 ,  Madison R Jenner  1  2 ,  Priscilla S Chan  2 ,  Ashley B Morrison  2 ,  Emily C Shen  2 ,  Silvia G Hererra  2 ,  Chinmaya U Joisa  4 ,  Naim U Rashid  2  5 ,  Alina C Iuga  2  6 ,  Shawn M Gomez  1  4 ,  Lisa Miller-Phillips  7  8 ,  Stefan Boeck  7  9 ,  Volker Heinemann  7  9 ,  Michael Haas  7  9 ,  Steffen Ormanns  9  10 ,  Gary L Johnson  1  2 ,  Jen Jen Yeh  1  2  11
Affiliations
  • 1. Department of Pharmacology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.
  • 2. Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.
  • 3. Department of Cell Biology and Physiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.
  • 4. Joint Department of Biomedical Engineering, University of North Carolina at Chapel Hill and North Carolina State University, Chapel Hill, North Carolina.
  • 5. Department of Biostatistics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.
  • 6. Department of Pathology and Laboratory Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.
  • 7. Department of Internal Medicine III and Comprehensive Cancer Center, Klinikum Grosshadern, Ludwig-Maximilians-University of Munich, Munich, Germany.
  • 8. Division of Hematology and Oncology, Department of Medicine and Helen Diller Family Comprehensive Cancer Center, UCSF, San Francisco, California.
  • 9. German Cancer Consortium (DKTK), Partner Site Munich, Munich, Germany.
  • 10. Institute of Pathology, Faculty of Medicine, Ludwig-Maximilians-University, Munich, Germany.
  • 11. Department of Surgery, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.
  • # Contributed equally.
PMID: 39632628 DOI: 10.1158/2159-8290.CD-23-1480
Abstract

We provide a comprehensive tumor-intrinsic kinome landscape that provides a roadmap for the use of kinase inhibitors in PDAC treatment approaches.

Products