Grape Seed Proanthocyanins Extract Ameliorates the Neurotoxicity Induced by Fluoride Through mTOR/p70s6k Signaling Pathway in Vivo and in Vitro

  • Cell Biochem Biophys. 2025 Sep 27. doi: 10.1007/s12013-025-01916-x.
Wenxin Zhao  1  2 Zelin Gong  1  2 Benjie Wang  1  2 Zhiyu Wu  1  2 Yiyuan Guo  1  2 Shurong Wang  1  2 Hao Zhai  1  2 Xiaomei Zheng  1  2 Lu Yang  3  4
Affiliations
  • 1. Department of Preventive Medicine, School of Medicine, Shihezi University, North 2th Road, Shihezi, 832000, Xinjiang, People's Republic of China.
  • 2. Key Laboratory of Xinjiang Endemic and Ethnic Diseases (Ministry of Education), School of Medicine, Shihezi University, Shihezi, Xinjiang, People's Republic of China.
  • 3. Department of Preventive Medicine, School of Medicine, Shihezi University, North 2th Road, Shihezi, 832000, Xinjiang, People's Republic of China. [email protected].
  • 4. Key Laboratory of Xinjiang Endemic and Ethnic Diseases (Ministry of Education), School of Medicine, Shihezi University, Shihezi, Xinjiang, People's Republic of China. [email protected].
Keywords
Autophagy; Grape seed proanthocyanidin extract (GSPE); Neurotoxicity; Sodium fluoride; mTOR/p70s6k.
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