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Rosiglitazone potassium

(Synonyms: BRL 49653 potassium)
173 Cited Publications
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Based on 173 publication(s) in Google Scholar

Rosiglitazone (BRL 49653) potassium is an orally active selective PPARγ agonist (EC50: 60 nM, Kd: 40 nM). Rosiglitazone potassium is a TRPC5 activator (EC50: 30 μM) and TRPM3 inhibitor. Rosiglitazone potassium can be used in the research of obesity and diabetes, senescence, ovarian cancer.

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  • Reinheit: 99.13%
  • CAS. Nr.: 316371-84-3
  • Formel: C18H18KN3O3S
  • Molecular Weight:395.52
  • Speicherung:
    Powder   -20°C, 3 years ; In solvent   -80°C, 6 months , -20°C, 1 month
  • Rosiglitazone potassium Chemical Structure
    Rosiglitazone potassium Chemical Structure
  • Experimental Validation Results for Rosiglitazone potassium
  • Experimental Validation Results for Rosiglitazone potassium
  • Experimental Validation Results for Rosiglitazone potassium
  • Experimental Validation Results for Rosiglitazone potassium
  • Experimental Validation Results for Rosiglitazone potassium
  • Experimental Validation Results for Rosiglitazone potassium
  • Experimental Validation Results for Rosiglitazone potassium
  • Experimental Validation Results for Rosiglitazone potassium
  • Experimental Validation Results for Rosiglitazone potassium
  • Experimental Validation Results for Rosiglitazone potassium
  • Experimental Validation Results for Rosiglitazone potassium
CAS. Nr.: 316371-84-3
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  • Rosiglitazone potassium Chemical Structure
    Rosiglitazone potassium Chemical Structure
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  • 1/16

    Rosiglitazone potassium purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Sep 10;16(1):8215. [Abstract]

    Customer Validation
     NECTIN4 mRNA levels in RT112 cells treated with 1μM Rosiglitazone and T0070907 (T007) for 72 h.

  • 1/16

    Rosiglitazone potassium purchased from MedChemExpress. Usage Cited in: Cell Metab. 2023 Nov 7;35(11):1915-1930.e8. [Abstract]

    Customer Validation
     C3H10T1/2 preadipocytes were treated with differentiation medium supplemented with 0.5 mM 3-isobutyl-1-methylxanthine, 1 μM Dexamethasone, 850 nM Insulin, 1 nM Triiodothyronine, 125 nm Indomethacin and 1 μM Rosiglitazone for 2 days and subsequently cultured in maintaining medium supplemented with 1 nM Triiodothyronine, 850 nM Insulin, and 1 μM Rosiglitazone for another 2 days. Differentiated adipocytes at day 4 were cultured in complete medium until used for experiments. Representative immunoblots of PGC-1α and UCP1 in beige adipocytes treated as indicated.

  • 1/16

    Rosiglitazone potassium purchased from MedChemExpress. Usage Cited in: Cell Metab. 2023 Dec 5;35(12):2165-2182.e7. [Abstract]

    Customer Validation
     Relative GDF15 mRNA expression and GDF15 release in human primary hepatocytes treated with 10 μM rosiglitazone for 48 h.

  • 1/16

    Rosiglitazone potassium purchased from MedChemExpress. Usage Cited in: Nat Commun. 2023 Jun 2;14(1):3208. [Abstract]

    Customer Validation
     C3H10T1/2 preadipocytes were cultured in DMEM supplemented with 10% FBS, 1% P/S. For adipogenic differentiation, confluent C3H10T1/2 preadipocytes were incubated with complete medium supplemented with 0.5 mM 3-isobutyl-1-methylxanthine, 1 μM Dexamethasone, 850 nM Insulin, 1 nm Triiodothyronine, 125 nm Indomethacin and 1 μM Rosiglitazone for 2 days. Then, cells were changed to the complete medium supplemented with 1 nM T3, 850 nM Insulin, and 1 μM Rosiglitazone for another 2 days. Differentiated adipocytes at day 4 were maintained in complete medium until used for experiments. Representative immunoblots of NRP1 and EPHA7 in differentiated brown adipocytes transfected with si-Rbm3 or si-NC.

  • 1/16

    Rosiglitazone potassium purchased from MedChemExpress. Usage Cited in: Carcinogenesis. 2023 May 27;44(3):242-251. [Abstract]

    Customer Validation
     Rosiglitazone (ROSI; 15, 30, 60, 120, 240 µM; 24 h) significantly inhibits the growth of NCI-H929 and OPM-2 cells.

  • 1/16

    Rosiglitazone potassium purchased from MedChemExpress. Usage Cited in: Cell Metab. 2021 Mar 2;33(3):581-597.e9. [Abstract]

    Customer Validation
     Protein expression of PPRC1 and PPARG in HepG2 cells exposed to PA and treated with RGZ (Rosiglitazone) (30 mmol/L; 24 h), as analyzed by western blot.

  • 1/16

    Rosiglitazone potassium purchased from MedChemExpress. Usage Cited in: Eur J Pharmacol. 2019 Jan 15:843:134-144. [Abstract]

    Customer Validation
     Protein levels of BACE1 and APP are measured by western blot assay in cerebral cortex of 12-month-old AD mice with different treatments (RSG and GW9662).

  • 1/16

    Rosiglitazone potassium purchased from MedChemExpress. Usage Cited in: Eur J Pharmacol. 2019 Jan 15:843:134-144. [Abstract]

    Customer Validation
     Protein levels of sAPPα and sAPPβ are measured by western blot assay in cerebral cortex of 12-month-old AD mice with different treatments (RSG and GW9662).

  • 1/16

    Rosiglitazone potassium purchased from MedChemExpress. Usage Cited in: Eur J Pharmacol. 2019 Jan 15:843:134-144. [Abstract]

    Customer Validation
     PPARγ level is determined by IF assay in 3×Tg-AD mice, 3×Tg-AD mice with RSG treatment, 3×Tg-AD-KO mice, 3×Tg-AD-KO mice with GW9662 stimulation.

  • 1/16

    Rosiglitazone potassium purchased from MedChemExpress. Usage Cited in: Free Radic Biol Med. 2018 Oct:126:259-268. [Abstract]

    Customer Validation
     Laser confocal microscope is performed to measure MMP indicated with the ratio of JC-1 Red/JC-1 Green. Nuclei are counterstained with DAPI (blue). Bar graphs represent the mean ± SD of red/green fluorescence intensity.

  • 1/16

    Rosiglitazone potassium purchased from MedChemExpress. Usage Cited in: Front Mol Neurosci. 2017 Sep 14;10:293. [Abstract]

    Customer Validation
     Rosiglitazone enhances the phosphorylation of insulin receptor substrate 1 (IRS1, phosphorylated at Ser 636/639), which is considered to be the main activator of the Akt/mTOR pathway by IGF-1R.

  • Rosiglitazone potassium