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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
621 Results for "
root
" in MedChemExpress (MCE) Product Catalog:
Products (621)
621 Results for "root" in MCE Product Catalog:
74
Category:
Anti-aging Celastraceae Plants Tripterygium wilfordii Hook. f. Biological Pesticide Research Agricultural Research Terpenoids Diterpenoids Disease Research Fields Cancer
Target:
47
47 Cited Publications
Art. -Nr.: HY-N0174
CAS. Nr.: 35825-57-1
Synonyms: Cryptotanshinon; Tanshinone c
37
Category:
Quinones Labiatae Terpenoids Samanea saman (Jacq.) Merr. Diterpenoids Plants Disease Research Fields Naphthalene Quinones Cancer
Target:
35
35 Cited Publications
Synonyms: GU17; ISL; Isoliquiritigen; SJ000286237
32
Category:
Pueraria edulis Pampan. Flavonoids Leguminosae Phenols Polyphenols Plants Disease Research Fields Cancer Isoflavones
Target:
28
28 Cited Publications
Forschungsgebiete:
SKF-96365 hydrochloride is a TRPC channel antagonist and store-operated calcium entry (SOCE) inhibitor. SKF-96365 hydrochloride reduces calcium ion influx by inhibiting the activity and expression of TRPC6, STIM1 and Orai1. SKF-96365 hydrochloride inhibits voltage-gated sodium current (cardiac INa/NaV1.5) and slows myocardial conduction. SKF-96365 hydrochloride inhibits phosphorylation/activation of CaMKIIγ and suppresses the downstream AKT signaling pathway. SKF-96365 hydrochloride induces G2/M phase cell cycle arrest, apoptosis and cytoprotective autophagy in colorectal cancer cells. SKF-96365 hydrochloride alleviates allergic rhinitis symptoms by reducing inflammatory cytokine levels. SKF-96365 hydrochloride reduces intracellular calcium overload, inhibits Homer1 expression, prevents nuclear damage and suppresses apoptosis. SKF-96365 hydrochloride inhibits the growth of colorectal cancer xenografts in nude mice . SKF-96365 hydrochloride is applicable to research related to allergic rhinitis, colorectal cancer, Parkinson's disease, persistent spontaneous nociception and hyperalgesia .
28
28 Cited Publications
Art. -Nr.: HY-125942
CAS. Nr.: 162849-90-3
Forschungsgebiete:
SKF-96365 is a TRPC channel antagonist and store-operated calcium entry (SOCE) inhibitor. SKF-96365 reduces calcium ion influx by inhibiting the activity and expression of TRPC6, STIM1 and Orai1. SKF-96365 inhibits voltage-gated sodium current (cardiac INa/NaV1.5) and slows myocardial conduction. SKF-96365 inhibits phosphorylation/activation of CaMKIIγ and suppresses the downstream AKT signaling pathway. SKF-96365 induces G2/M phase cell cycle arrest, apoptosis and cytoprotective autophagy in colorectal cancer cells. SKF-96365 alleviates allergic rhinitis symptoms by reducing inflammatory cytokine levels. SKF-96365 reduces intracellular calcium overload, inhibits Homer1 expression, prevents nuclear damage and suppresses apoptosis. SKF-96365 inhibits the growth of colorectal cancer xenografts in nude mice . SKF-96365 is applicable to research related to allergic rhinitis, colorectal cancer, Parkinson's disease, persistent spontaneous nociception and hyperalgesia .
16
16 Cited Publications
Synonyms: Sanguinarin chloride; Sanguinarium chloride; Pseudochelerythrine chloride
16
12
Category:
Monophenols Neurological Disease Phenols Plants Paeoniaceae Disease Research Fields Cancer Paeonia suffruticosa Andr.
Target:
12
12 Cited Publications
Art. -Nr.: HY-N0373
CAS. Nr.: 58749-23-8
12
12 Cited Publications
Synonyms: GSK-AHAB; GW856553X; SB856553
Target:
Forschungsgebiete:
Cardiovascular Disease Infection Neurological Disease Cancer
Losmapimod (GSK-AHAB; GW856553X) is an orally active p38α/β MAPK inhibitor, with pKi values of 8.1 and 7.6 for p38α and p38β, respectively. Losmapimod reduces DUX4 expression, thus exerting efficacy in facioscapulohumeral muscular dystrophy. By inhibiting MAPK/NF-κB, Losmapimod reduces apoptosis of epileptiform hippocampal neurons, and exhibits anti-allodynia and anti-hyperalgesic activities. Losmapimod blocks the entry and fusion of Lassa fever virus (LASV). Losmapimod overcomes tyrosine kinase inhibitor resistance in non-small cell lung cancer (NSCLC). Losmapimod inhibits myocardial senescence and inflammation, and possesses cardioprotective activity against cardiotoxicity .
10
10 Cited Publications
Synonyms: Norcoclaurine; Demethyl-Coclaurine
9
9 Cited Publications
Art. -Nr.: HY-N0037
CAS. Nr.: 39011-90-0
Category:
Other Monoterpenes Paeonia lactiflora Pall. Terpenoids Plants Paeoniaceae Disease Research Fields Inflammation/Immunology
Target:
8
8 Cited Publications
Art. -Nr.: HY-W004599
CAS. Nr.: 1245-13-2
Bicinchoninic acid (compound 8) is an AHAS inhibitor, in an in vivo bioassay targeting the root growth inhibition of rapeseed, at a concentration of 100 μg/mL, it exhibited very low activity, with only a 1.4% root length inhibition rate .
6
6 Cited Publications
Art. -Nr.: HY-N1381
CAS. Nr.: 13137-64-9
Category:
Asclepiadaceae Plants Periploca sepium Bunge Disease Research Fields Inflammation/Immunology Steroids
Target:
5
5 Cited Publications
Art. -Nr.: HY-N1376
CAS. Nr.: 38243-03-7
Synonyms: (20R)-Propanaxadiol; R-ginsenoside Rg3
Category:
Panax ginseng C. A. Meyer Triterpenes Terpenoids Plants Disease Research Fields Araliaceae Cancer
Target:
5
5 Cited Publications
Art. -Nr.: HY-N4187
CAS. Nr.: 144506-15-0
5
5 Cited Publications
Target:
Forschungsgebiete:
Cardiovascular Disease Neurological Disease Inflammation/Immunology
MRS 1523 is a potent and selective adenosine A3 receptor antagonist with Ki values of 18.9 nM and 113 nM for human and rat A3 receptors, respectively. In rat this corresponds to selectivities of 140- and 18-fold vs A1 and A2A receptors, respectively. MRS 1523 can exert antihyperalgesic effect through N-type Ca channel block and action potential inhibition in isolated rat dorsal root ganglion (DRG) neurons .
4
4 Cited Publications
Art. -Nr.: HY-D0155
CAS. Nr.: 288574-78-7
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
