Art. -Nr.: HY-N0037

Albiflorin

9 Cited Publications

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Based on 9 publication(s) in Google Scholar

Albiflorin, a major constituent contained in peony root, is a brain-penetrant monoterpene glycoside with neuroprotective effects. Albiflorin also has anti-inflammatory, antioxidant and antinociceptive effects.

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Reinheit: 98.67%
CAS. Nr.: 39011-90-0
Formel: C₂₃H₂₈O₁₁
Molecular Weight:480.46

Speicherung:

Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year

Albiflorin Chemical Structure

CAS. Nr.: 39011-90-0

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Biologische Aktivität
- Beschreibung
- In Vitro
- In Vivo
Chemical Information
Publications (9)
Lösungsmittel & Löslichkeit
- In Vitro
- In Vivo
Reinheit & Dokumentation
Verweise
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

In Vitro

Albiflorin (50-200 μM; pretreated for 3 hours; PC12 cells) treatment significantly ameliorates glutamate (Glu)-induced reduction of cell viability^[1].
Albiflorin (100 μM; pretreated for 3 hours; PC12 cells) treatment significantly ameliorates Glu-induced reduction of nuclear and mitochondrial apoptotic alteration, reactive oxygen species accumulation, and B-cell lymphoma 2 (Bcl-2)/Bax ratio^[1].
Albiflorin (100 μM; pretreated for 3 hours; PC12 cells) treatment enhances phosphorylation of AKT and its downstream element GSK-3β^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[1]

Cell Line:

PC12 cells
Concentration:

50 μM, 100 μM, 200 μM
Incubation Time:

Pretreated for 3 hours
Result:

Significantly ameliorated Glu-induced reduction of cell viability.

Apoptosis Analysis^[1]

Cell Line:

PC12 cells
Concentration:

100 μM
Incubation Time:

Pretreated for 3 hours
Result:

Significantly ameliorated Glu-induced reduction of nuclear and mitochondrial apoptotic alteration.

Western Blot Analysis^[1]

Cell Line:

PC12 cells
Concentration:

100 μM
Incubation Time:

Pretreated for 3 hours
Result:

Enhanced phosphorylation of AKT and its downstream element GSK-3β.

In Vivo

Albiflorin (50 mg/kg; intraperitoneal injection; once a day; for 15 days; Wistar rats) treatment significantly increases the paw withdrawal threshold (PWT) and attenuates neuropathic pain on the 11th and 15th day after surgery in rats, inhibits the activation of p38 MAPK pathway in spinal microglia and subsequent upregulated IL-1β and TNF-α and displays remarkable effects on inhibiting the activation of astrocytes, suppressing the overelevated expression of phosphorylation of c-JNK (p-JNK) in astrocytes, and decreasing the content of chemokine CXCL1 in the spinal cord^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Wistar rats (7-week-old; 200-220 g) bearing chronic constriction injury (CCI)^[2]
Dosage:

50 mg/kg
Administration:

Intraperitoneal injection; once a day; for 15 days
Result:

Significantly increased the paw withdrawal threshold (PWT) on the 11th and 15th day after surgery.

Chemical Information

CAS. Nr. 39011-90-0
Appearance Solid
Molecular Weight 480.46
Formel C₂₃H₂₈O₁₁
Color White to off-white
SMILES

O=C(C1=CC=CC=C1)OC[C@@]2([C@@]([C@H](O)C[C@@]3(OC2=O)C)([H])C4)[C@]43O[C@@H]5O[C@@H]([C@@H](O)[C@H](O)[C@H]5O)CO
Structure Classification
- Terpenoids
- Other Monoterpenes
Initial Source
Versand

Room temperature in continental US; may vary elsewhere.

Speicherung

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	2 years
	-20°C	1 year

Publications (9)

All Cell Proliferation/Viability AssayIFWBRT-PCRHistological Imaging/Staining

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Journal Impact Factor

Antioxidants

Integration of Transcriptomic Analysis, Network Pharmacology, and Experimental Validation Demonstrates Enhanced Muscle-Protective Effects of Ethanol Extract of Jakyak-Gamcho-Tang. [Abstract]

2025 Jun 27;14(7):795. PMID: 40722900
Drug Des Devel Ther

Exploration of the Active Component and Mechanisms of Shengyu Decoction Against Myelosuppression Using Network Pharmacology and in vitro Experimental Validation. [Abstract]

2024 Jun 20:18:2405-2420. PMID: 38915868
Int Immunopharmacol

Albiflorin contributes to Xuebijing-mediated protection against sepsis-associated acute kidney injury by modulating the succinate-PFKFB3 immunometabolic axis. [Abstract]

2026 May 14:182:116841. PMID: 42134292
Int Immunopharmacol

Albiflorin inhibits osteoclastogenesis and titanium particles-induced osteolysis via inhibition of ROS accumulation and the PI3K/AKT signaling pathway. [Abstract]

2024 Sep 27;142(Pt B):113245. PMID: 39340985

Albiflorin purchased from MedChemExpress. Usage Cited in: Int Immunopharmacol. 2024 Sep 27;142(Pt B):113245. [Abstract]

CCK8 assay of Albiflorin (AF) (0, 1, 2, 5, 10, 20, 50, 100, 200, 500 μM) on RAW264.7 cells viability for 24, 72 h.

Albiflorin purchased from MedChemExpress. Usage Cited in: Int Immunopharmacol. 2024 Sep 27;142(Pt B):113245. [Abstract]

Representative images of F-actin staining showing RAW264.7 cells treated with Albiflorin (AF) (20, 50 μM).

Albiflorin purchased from MedChemExpress. Usage Cited in: Int Immunopharmacol. 2024 Sep 27;142(Pt B):113245. [Abstract]

The Western Blot showing the levels of osteoclastogenesis related proteins treated with Albiflorin (AF) (20, 50 μM).

Albiflorin purchased from MedChemExpress. Usage Cited in: Int Immunopharmacol. 2024 Sep 27;142(Pt B):113245. [Abstract]

RT-PCR results showing expression levels of CTSK, NFATc1, Acp5, and DCSATMP mRNA treated with Albiflorin (AF) (20, 50 μM).

Albiflorin purchased from MedChemExpress. Usage Cited in: Int Immunopharmacol. 2024 Sep 27;142(Pt B):113245. [Abstract]

H&E staining of cranial tissues of mice treated with Albiflorin (AF) (10 mg/kg, i.p.).
Naunyn Schmiedebergs Arch Pharmacol

Integrated experimental and network pharmacology analyses reveal inhibitory effects of albiflorin on renal cell carcinoma cells. [Abstract]

2026 May 27. PMID: 42201344
J Pharm Pharmacol

Albiflorin alleviation efficacy in osteoarthritis injury using in-vivo and in-vitro models. [Abstract]

2023 Oct 5;75(10):1332-1343. PMID: 37403239
Immun Inflamm Dis

Effects of albiflorin on oxidative stress and inflammatory responses in rats with acute spinal cord injury. [Abstract]

2023 Sep;11(9):e1015. PMID: 37773716
Immunopharmacol Immunotoxicol

Albiflorin ameliorates neuroinflammation and exerts neuroprotective effects in Parkinson's disease models. [Abstract]

2025 Apr;47(2):201-212. PMID: 39924948
SSRN

2025 Aug 13.

Lösungsmittel & Löslichkeit

In Vitro:

DMSO : ≥ 100 mg/mL (208.13 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H₂O : 100 mg/mL (208.13 mM; Need ultrasonic)

* "≥" means soluble, but saturation unknown.

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

2.0813 mL

10.4067 mL

20.8134 mL

5 mM

0.4163 mL

2.0813 mL

4.1627 mL

10 mM

0.2081 mL

1.0407 mL

2.0813 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

Stock Solution Working Solution

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline

Solubility: ≥ 2.5 mg/mL (5.20 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)

Solubility: ≥ 2.5 mg/mL (5.20 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil

Solubility: ≥ 2.5 mg/mL (5.20 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

Working Solution

For the following dissolution methods, please prepare the working solution directly:

It is recommended to prepare fresh solutions and use them promptly within a short period of time.

The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: PBS

Solubility: 100 mg/mL (208.13 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage Dosage
mg/kg
Animal Weight (Per Animal) Animal Weight (Per Animal)
g
Dosing Volume (Per Animal) Dosing Volume (Per Animal)
μL
Number of Animals Number of Animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Working solution concentration: 0.22 mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact

MedChemExpress (MCE) .

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (289 KB)
SDS (254 KB)
- English - EN (254 KB)
- Français - FR (254 KB)
- Deutsch - DE (254 KB)
- Norwegian - NO (254 KB)
- Español - ES (254 KB)
- Swedish - SV (254 KB)
- Italian - IT (254 KB)
- Korean - KR (254 KB)
- Portuguese - PT (254 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Wang D, et al. Neuroprotective effects of paeoniflorin, but not the isomer albiflorin, are associated with the suppression of intracellular calcium and calcium/calmodulin protein kinase II in PC12 cells. J Mol Neurosci. 2013 Oct;51(2):581-90. [Content Brief]

[2]. Jianyu Zhou, et al. Paeoniflorin and Albiflorin Attenuate Neuropathic Pain via MAPK Pathway in Chronic Constriction Injury Rats. Evid Based Complement Alternat Med. 2016;2016:8082753. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO / H₂O	1 mM	2.0813 mL	10.4067 mL	20.8134 mL	52.0335 mL
	5 mM	0.4163 mL	2.0813 mL	4.1627 mL	10.4067 mL
	10 mM	0.2081 mL	1.0407 mL	2.0813 mL	5.2033 mL
	15 mM	0.1388 mL	0.6938 mL	1.3876 mL	3.4689 mL
	20 mM	0.1041 mL	0.5203 mL	1.0407 mL	2.6017 mL
	25 mM	0.0833 mL	0.4163 mL	0.8325 mL	2.0813 mL
	30 mM	0.0694 mL	0.3469 mL	0.6938 mL	1.7344 mL
	40 mM	0.0520 mL	0.2602 mL	0.5203 mL	1.3008 mL
	50 mM	0.0416 mL	0.2081 mL	0.4163 mL	1.0407 mL
	60 mM	0.0347 mL	0.1734 mL	0.3469 mL	0.8672 mL
	80 mM	0.0260 mL	0.1301 mL	0.2602 mL	0.6504 mL
	100 mM	0.0208 mL	0.1041 mL	0.2081 mL	0.5203 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Keywords

Albiflorin

9 Cited Publications

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Albiflorin

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Publications Citing Use of MedChemExpress (MCE) Albiflorin

Biologische Aktivität

Chemical Information

Publications (9)

Lösungsmittel & Löslichkeit

Reinheit & Dokumentation

Verweise

Help & FAQs

Complete Stock Solution Preparation Table

Albiflorin Related Classifications

HY-N0037 Related Classifications