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Art. -Nr.: HY-149267

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STING agonist-30

STING agonist-30 is a potent STING agonist. STING agonist-30 exhibits STING-dependent immune activation. STING agonist-30 has extensive inhibitory effects on various viruses, including the herpes simplex virus (HSV), rotavirus, and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).

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CAS. Nr.: 2951078-67-2
Formel: C₁₅H₁₆N₄O₈
Molecular Weight:380.31

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (266 KB)

STING agonist-30 Chemical Structure

CAS. Nr.: 2951078-67-2

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Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- Cellular Effect
- In Vitro
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

Cellular Effect

Cell Line	Type	Value	Description	References
HEK-293T	IC₅₀	22.36 μM Compound: 23	Cytotoxicity against STING-deficient human 293T cells assessed as cell viability measured after 72 hrs by MTT assay Cytotoxicity against STING-deficient human 293T cells assessed as cell viability measured after 72 hrs by MTT assay	[PMID: 36758305]
HT-1080	IC₅₀	9.31 μM Compound: 23	Cytotoxicity against human HT-1080 cells assessed as cell viability measured after 72 hrs by MTT assay Cytotoxicity against human HT-1080 cells assessed as cell viability measured after 72 hrs by MTT assay	[PMID: 36758305]
RAW264.7	IC₅₀	8.69 μM Compound: 23	Cytotoxicity against mouse RAW264.7 cells assessed as cell viability measured after 72 hrs by MTT assay Cytotoxicity against mouse RAW264.7 cells assessed as cell viability measured after 72 hrs by MTT assay	[PMID: 36758305]
Vero	IC₅₀	28.35 μM Compound: 23	Cytotoxicity against interferon production defective African green monkey Vero cells assessed as cell viability measured after 72 hrs by MTT assay Cytotoxicity against interferon production defective African green monkey Vero cells assessed as cell viability measured after 72 hrs by MTT assay	[PMID: 36758305]

In Vitro

STING agonist-30 (compound 23; 20 μM; 5 h) increases TBK1 phosphorylation in wild-type HT1080 cells but not in HT1080 STING-KO cells^[1].
STING agonist-30 (20 μM; 8 h) boosts interferon β (IFNβ) and TNF-α expression^[1].
STING agonist-30 (0-20 μM; 5 h) activates both mouse and human STING in a dose-dependent manner^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis^[1]

Cell Line:

HT1080, THP1, BMDMs and MEFs
Concentration:

2.5, 5, 10, and 20 μM
Incubation Time:

5 hours
Result:

Induced obvious dimeric STING bands.

Chemical Information

CAS. Nr. 2951078-67-2
Molecular Weight 380.31
Formel C₁₅H₁₆N₄O₈
SMILES

O=C(C1=CC=C(O1)[N+]([O-])=O)NCCCCCNC(C2=CC=C(O2)[N+]([O-])=O)=O
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (266 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Zang R, et, al. Design and syntheses of a bimolecular STING agonist based on the covalent STING antagonist. Eur J Med Chem. 2023 Mar 15;250:115184. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

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100 mg

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