UMB68 sodium
UMB68 sodium is a selective GHB receptor ligand. UMB68 sodium displaces [3H]NCS-382 with an IC50 of 38 nM in rat cerebrocortical membranes. UMB68 sodium has no significant affinity at GABAB receptors, cannot be metabolized to GABA-active compounds.
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- CAS. Nr.: 581099-89-0
- Formel: C6H11NaO3
- Molecular Weight:154.14
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Chemical Information
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Help & FAQs
Biologische Aktivität
GHB receptor[1]
UMB68 inhibits [3H]NCS382 (16 nM) binding to the rat cerebrocortical membranes, with an IC50 of 38 nM compared with 25 μM for GHB[1].
UMB68 shows no affinity (IC50 >100 μM) at GABA(A) or GABA(B) receptors[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Adult male Sprague-Dawley rats (250-300 g) are carried out discrimination training[1]
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Dosage:320, 660, 1000, 1778 mg/kg
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Administration:I.p. injection
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Result:Caused vehicle-lever responding up to a dose (1778 mg/kg) that decreased markedly or eliminated lever pressing.
Chemical Information
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CAS. Nr. 581099-89-0
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Molecular Weight 154.14
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Formel C6H11NaO3
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SMILES
CC(C)(O)CCC(O[Na])=O
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
UMB68 sodium Related Classifications
HY-135034 Related Classifications
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