2412195-89-0
2412195-89-0
Chemical Structure
PI3Kδ/γ-IN-2
- CAS No.: 2412195-89-0
- Formula:C25H21ClN8O
- Molecular Weight:484.94
IUPAC Name: (S)-2,4-diamino-6-(6-(5-chloro-4-oxo-3-phenyl-3,4-dihydroquinazolin-2-yl)-5-azaspiro[2.4]heptan-5-yl)pyrimidine-5-carbonitrile
InChIKey: DEQCFSACIVEXND-SFHVURJKSA-N
SMILES: N#CC1=C(N=C(N=C1N2CC3(C[C@H]2C4=NC5=CC=CC(Cl)=C5C(N4C6=CC=CC=C6)=O)CC3)N)N
Biological Activity: PI3Kδ/γ-IN-2 is a potent PI3Kδ and PI3Kγ dual inhibitor with IC50s of 1 nM and 4.3 nM, respectively. PI3Kδ/γ-IN-2 has favorable oral bioavailability. PI3Kδ/γ-IN-2 has potential for battling B-cell malignancies[1].
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PI3Kδ/γ-IN-2 | PI3Kδ/γ-IN-2 is a potent PI3Kδ and PI3Kγ dual inhibitor with IC50s of 1 nM and 4.3 nM, respectively. PI3Kδ/γ-IN-2 has favorable oral bioavailability. PI3Kδ/γ-IN-2 has potential for battling B-cell malignancies. | |||||||||||||||||||||
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