GPR65 - G protein-coupled receptor 65 Gene

Also Known as TDAG8; hTDAG8

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 8477

About GPR65

Cytogenetic location: 14q31.3 Genomic coordinates (GRCh38): 14:88,005,135-88,014,811 (from NCBI)

This gene has 1 transcript (splice variant), 175 orthologues and 16 paralogues. Broad expression in appendix (RPKM 6.3), bone marrow (RPKM 5.3) and 18 other tissues.

Summary

Enables G protein-coupled receptor activity. Involved in several processes, including actin Cytoskeleton reorganization; activation of GTPase activity; and positive regulation of stress fiber assembly. Located in plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]

GPR65 Products (1)

mRNA Protein Name
NM_003608.4 NP_003599.2 psychosine receptor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables G protein-coupled receptor activity IDA
IDA: Inferred from direct assay
15618224 GOA
Biological Process GO Annotation Evidence References Source
involved in G protein-coupled receptor signaling pathway IDA
IDA: Inferred from direct assay
15618224 GOA
involved in activation of GTPase activity IDA
IDA: Inferred from direct assay
15618224 GOA
involved in adenylate cyclase-activating G protein-coupled receptor signaling pathway IDA
IDA: Inferred from direct assay
15618224 GOA
involved in positive regulation of stress fiber assembly IDA
IDA: Inferred from direct assay
15618224 GOA
involved in response to acidic pH IDA
IDA: Inferred from direct assay
15618224 GOA
Cellular Component GO Annotation Evidence References Source
located in plasma membrane IDA
IDA: Inferred from direct assay
15618224 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

GPR65 Protein Structure

7tm_1

7tm_1: 7 transmembrane receptor (rhodopsin family) (36 - 290)

  • 0
  • 100
  • 200
  • 300
  • 337 a.a.
Protein Preferred Names Protein Names

psychosine receptor

  • T-cell death-associated gene 8 protein

Related Diseases

Diseases Alias
Gastric Cancer

  • Stomach Cancer

  • Gastric Carcinoma

  • Stomach Carcinoma

  • Gastric Cancer, Somatic

  • Gastric Neoplasm

  • Carcinoma Of Stomach

  • Stomach Neoplasms

  • Malignant Neoplasm Of Stomach

  • Gastric Cancer Risk After H. Pylori Infection

  • Cancer Of The Stomach

  • Adult Stomach Cancer

  • Adult Stomach Carcinoma

  • GASC

  • Gastric Cancer Intestinal

  • Gastric Cancers

  • Gastric Carcinomas

  • Cancer, Gastric

  • Stomach Neoplasm

  • Malignant Neoplasm Of Body Of Stomach

  • Malignant Tumor Of Lesser Curve Of Stomach

  • Gastrocarcinoma Of Unspecified Site

  • Leather Bottle Stomach

  • Carcinoma Of Fundus Of Stomach

  • Cancer Of Fundus Of Stomach

  • Primary Malignant Neoplasm Of Body Of Stomach

  • Cancer Of Body Of Stomach

  • Primary Malignant Neoplasm Of Pyloric Antrum

  • Pyloric Antrum Cancer

  • Malignant Tumour Of Stomach
Aleutian Mink Disease

  • Aleutian Disease
Thrombocytopenia

  • Low Platelet Count

  • Low Platelets

  • Decreased Platelets

  • Platelet Dysfunction Nos
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (7)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-149164 BTB09089 Agonist 99.39% Unkown
HY-162734 BRD5075 Activator 98.04% Unkown
HY-162735 BRD5080 Activator 99.44% Unkown
HY-W193844 MLS001006105 Agonist 95.49% Unkown
HY-RS05730 GPR65 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17039 Gpr65 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23483 Gpr65 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta GPR65 VGNC VGNC:73140
Bos taurus GPR65 VGNC VGNC:29596
Mus musculus GPR65 MGD MGI:108031
Rattus norvegicus GPR65 RGD RGD:1311832
Felis catus GPR65 VGNC VGNC:67437
Canis familiaris GPR65 VGNC VGNC:41442
Others GPR65 NCBI