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United States

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Cat. No.: HY-124590

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IDX-17119

IDX-17119 is a non-nucleoside HCV NS5B RdRp inhibitor with an IC₅₀ of 0.4 nM.

For research use only. We do not sell to patients.

CAS No.: 1987906-92-2
Formula: C₂₆H₂₆N₇O₄P
Molecular Weight:531.50

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (267 KB)

IDX-17119 Chemical Structure

CAS No.: 1987906-92-2

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity

Description

IDX-17119 is a non-nucleoside HCV NS5B RdRp inhibitor with an IC₅₀ of 0.4 nM^[1].

Chemical Information

CAS No. 1987906-92-2
Molecular Weight 531.50
Formula C₂₆H₂₆N₇O₄P
SMILES

O=C(C1=CN(C2=CC=C(C3=NN4C(N)=CC(C)=NC4=C3)C=C2)N=C1NP(OC)(C5=CC=C(C)C=C5C)=O)O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Protocols

All Cell Biology

Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (267 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. • Manjula Saravanan, et al., The effect of genotype variation and M423 resistance mutations to the binding of phosphonomidate-based inhibitor IDX17119 with the thumb-II domain of Hepatitis C virus RdRp: an integrated molecular dynamics and binding free energy study, 2022 49(2):1-11.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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